After so long a persons body will just adjust to the chemical. It is like drinking coffee. The first time we drink a cup we feel wired and after a few years 1 cup is just not enough
Tolerance means that an increased amount of the drug is needed to achieve the same effect as before. Dependence can be physical or psychological. Dependence is referring to a need for the drug in order to function normally. Someone that is dependent on a drug likely has a high tolerance for the drug. However, someone can have a high tolerance for the drug and not go through withdrawals or have other negative effects when the drug is not used anymore.
Tolerance to a drug (so that higher and higher amounts are needed in order to obtain the same initial effect) and dependence - both are part of the physical addiction. Psychological addiction does not involve physical tolerance and dependence, but can be difficult to treat, unless there is motivation to kick the habit.
No, pain tolerance and drug tolerance are two almost completely different things. Pain tolerance is mostly psychological; basically how much discomfort you can take before you cave. If a person lives with chronic pain or painful injuries for an extended period of time, the person can eventually get used to it. The mind eventually can rework itself to set that level of pain as its zero point. You still feel the pain, but it doesn't bother you anymore. Drug tolerance (ie painkillers) is physical: your brain is used to a certain level of the drug, and requires more of the drug to feel the effects. Drug tolerance is often the immediate precursor to drug addiction. People with high tolerances for pain often become tolerant of painkillers sometime in their lives, but eventually stop relying on drugs at all.
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