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When a person attempts to stop using the opiate, they will go through withdrawal for about one week. Post acute withdrawal symptoms last much longer than that and include extreme sensitivity to pain as the natural pain receptors have vanished. The pain tolerance that a normal person has is no longer present in the opiate addict. They also experience a complete lack of motivation because the natural receptors are gone.

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15y ago
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10y ago

Opiates stop bowel movements, it's called gastric stasis. The lining of bowels contains mu opioid receptors and they get activated by opiates/opioids, producing constipation and GS.

When opiates are finally eliminated from the body, bowels start to "move" again, with more intensity than previously. This can be alleviated by taking loperamide, non-addictive opioid used for treatment of diarrhea.

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Q: Why do opiate withdrawals cause you to have diarrhea?
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