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Renal failure and cirrhosis cause delayed clearance of prolactin as it is metabolized by both the kidney and liver the serum prolactin concentration is high in patients who have chronic renal failure and returns to normal after renal transplantation . The major mechanism is a three-fold increase in prolactin secretion, and there is a one-third decrease in metabolic clearance rate

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Q: Why does renal failure lead to hyperprolactinemia?
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