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If by able you mean UNABLE, that is simple. A protein's function is determined entirely upon its shape. If you change the shape of a protein, for example, unfolding it, you change its function and make it unable to perform its job in a cell.

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Q: Why does unfolding a protein make it able to do its job in a living organism?
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Why does unfolding a protein make it not able to its job in a living organism?

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