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The two best things you could look at would be making sure the tires are balanced (most auto shops will do it for free if you ask them to check it out) and also take a look at your ball joints. If the ball joints don't have any cracks/ware in the rubber doughnut then those should be fine.

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Q: Why does your Chevy 1999 S10 4.3 4x4 run rough at highway speeds?
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