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Fasciola is a blood sucking parasite, it sucks 0.5ml blood/fluke/day. During sucking it removes plasma proteins, albumin. This results in fluid balance disturbance. Normally there is a balance between intravascular space and extravascular space. However, when albumin are lost from intravascular space by effect of fasciola, it will become less concentrated where as the fluid content become high. The fluid content become lower in extravascular space or interstitial tissues as compared to intravascular. Therefore, fluid move from intravascularspace to interstitial tissues. Due to gravity oedema occur in the ventral or mandibular area.
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