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Both Myoglobin and Haemoglobin binds to oxygen, but they differ in many aspects.

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Myoglobin: muscle tissues

Haemoblogin: red blood cells (whole body)

Main function:

Myoglobin: stores oxygen (in muscle tissues)

Haemoglobin: Oxygenation of tissues (whole body)

Waste (CO2) collection (whole body)

gas exchange (lungs, tissues)

Oxygen carrying capacity:

Myoglobin: monomeric = one heme prosthetic group, one iron atom

Haemoglobin: tetrameric = four heme prosthetic groups, four iron atoms.

Structure

Myoglobin: secondary and tertiary, no allosteric interaction

Haemoglobin: quaternary structure, allosteric interaction, different affinity

Affinity to oxygen

Myoglobin: Oxidation (Fe2+ → Fe3+) prevents oxygen binding.

Haemoglobin: requirement specific affinity:

(gradually increasing in the lungs, . gradually decreasing at the tissues)

Prefered binding

Myoglobin: Carbon monoxide preferred to Oxygen.

Haemoglobin: Oxygen, carbon dioxide

While in cases of hugely increased demand, myoglobin releases oxygen for metabolism, but, in the long run haemoglobin is more suitable for the purpose.

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Q: Why hemoglobin is better long distance oxygen transporter than myoglobin?
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One advantage hemoglobin has over myoglobin as a respiratory pigment is that?

Cooperative binding. Hemoglobin can load and unload oxygen better than myoglobin. So it is kore sensitive to changes in the environment, vs. Myoglobin


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Is carbon dioxide is more toxic than carbon monoxide?

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