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when an electrophile attacks at 2 or 5 position we get an intermediate in which + charge is on the ring but when the attack is on 3 or 4 position the + charge get on nitrogen atom which is the strongly electronegative in the ring and get destabilised. and hence the electrophile prefer to attack on 2 or 5 position
What else can I help you with?
Why the electrophilic substitution going to occur in furon thiophene and pyrole?
Electrophilic substitution occurs in furan, thiophene, and pyrrole because these compounds have a lone pair of electrons on the heteroatom (oxygen, sulfur, or nitrogen), making them nucleophilic and reactive towards electrophiles. The aromaticity of these compounds is also maintained during the substitution reaction, making them favorable candidates for electrophilic substitution.
What are the Major organic products of Pyrrole with D2SO4?
The major organic product of pyrrole with D2SO4 is deuterated pyrrole (C4D5N) due to the deuterium exchange. Other possible products could include deuterated intermediates or side products depending on the reaction conditions and the presence of other functional groups.
Why pyrrole does not react with hydrocloric acid?
Pyrrole does not react with hydrochloric acid because the nitrogen atom in the pyrrole ring is part of an aromatic system. The lone pair of electrons on the nitrogen atom is delocalized within the aromatic ring, making it less available for reaction with acids.
What is the pKa value of protonated pyrrole?
The pKa value of protonated pyrrole is approximately 0.8.
Why furan is more reactive than pyrrole and thiophene?
Furan is more reactive than Pyrrole because it is less stable as it contains an extra lone pair than that of pyrrole, which is available for attack of an acid, results in the destabilization of the ring.
Why pyrrole is less basic than pyridine?
Pyrrole is less basic than pyridine because the lone pair of electrons on the nitrogen in pyrrole is part of the aromatic system and less available for donation compared to the lone pair on the nitrogen in pyridine. This makes pyridine more basic than pyrrole.
What is a heterocylic amine?
Pyrrole is a 5 membered ring heterocylic amine , the fused heterocylic form of it is Indole (Benzo [b] Pyrrole)
What are pyrrole ring containing drugs?
Atorvastatin
Why do 5-membered ring aromatic heterocycles pyrrole and furan undergo electrophilic substitution more rapidly than benzene while 6-membered ring heterocycles like pyridine are less reactive than Benz?
pyridine is less reactive than benzene because when we form its conjugate base then it'll b more stable than dat of benzene.. so more stabler means less reactive.......and also due to more resonance in benzene it will b more reactive...same 4 furan and pyrrole
Is bone oil used to make pyrrole?
No, bone oil is not used to make pyrrole. Pyrrole is typically synthesized from chemicals like butanone and ammonia, using specific laboratory procedures. Bone oil, derived from the destructive distillation of bones, is mainly used for industrial purposes such as making soaps, lubricants, and leather treatments.
What is the molar mass of pyrrole?
67.09 grams/mole
What are the key differences between pyrrole and pyridine in terms of their chemical structures and properties?
Pyrrole and pyridine are both aromatic compounds, but they differ in their chemical structures and properties. Pyrrole has a five-membered ring with four carbon atoms and one nitrogen atom, while pyridine has a six-membered ring with five carbon atoms and one nitrogen atom. Pyrrole is more reactive due to its higher electron density, while pyridine is less reactive and more stable. Pyrrole is a stronger base than pyridine because its nitrogen atom is more basic. Additionally, pyrrole is more acidic than pyridine because its nitrogen atom can donate a proton more easily.
