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Whenever a new life is formed, mistakes (random mutations) are naturally made.
If my parents give me a genetic mutation, my brother might have that same mutation. If I then have a baby with my brother, the baby is more likely to have the mutation and have it be more serious.
That's why the royal families, in general, have weak immune systems- they all married within the family. Say the first couple kings happened to be a little more susceptible to disease than most people. After they married their sisters and their cousins, everyone ended up with that same mutation and it got more and more severe over the generations.
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