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To answer this question, a few facts have to be established. It is generally known that oil and water do not mix (one can see this when attempting to shake up a bottle of oil and vinegar salad dressing). With this, the human body's blood is like water and the drug in injection is like oil. When an intramuscular injection is giving, the oil-like drug sits in the muscle as water-like blood passes by. The drug does not want to readily dissolve into the blood so it will sit in the muscle. Over time though, the blood will "wash" some of the drug from the muscle into the blood where the drug can reach its intended destination and thus carry out its effect.

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