To answer this question, a few facts have to be established. It is generally known that oil and water do not mix (one can see this when attempting to shake up a bottle of oil and vinegar salad dressing). With this, the human body's blood is like water and the drug in injection is like oil. When an intramuscular injection is giving, the oil-like drug sits in the muscle as water-like blood passes by. The drug does not want to readily dissolve into the blood so it will sit in the muscle. Over time though, the blood will "wash" some of the drug from the muscle into the blood where the drug can reach its intended destination and thus carry out its effect.
There is little blood flow to the fatty tissue where the solution is injected. The absorption rate will hence be slow and this will lead to a slow rate of onset.
Onset in pharmacology refers to the amount of time it takes for a drug to start producing its therapeutic effects after administration. This can vary depending on the drug's pharmacokinetics and route of administration. A fast onset means the drug acts quickly, while a slower onset implies a delayed response.
True.
Delayed onset muscle soreness
intramuscular
delayed onset muscle soreness doctor of medicine
Massage therapy has been shown to be effective in reducing delayed onset muscle soreness by improving blood flow and reducing inflammation in the muscles.
This article says that it isn't related to lactate acid buildup and suggests it might be caused by muscle tissue breakdown: http://www.sport-fitness-advisor.com/delayed-onset-muscle-soreness.html
No, sodium bicarbonate is typically given orally or intravenously, but not intramuscularly. Intramuscular injections are usually administered with medications that are specifically formulated for that route of administration.
Mustard
Massage can be effective in reducing the symptoms of delayed onset muscle soreness (DOMS) by improving blood flow and reducing inflammation in the muscles, leading to faster recovery and decreased pain.
The onset of pain after amputation usually occurs within days to weeks, although it may be delayed months or years.