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Guillian Barre Syndrome (GBS) is a disease which falls into a class of diseases called acute inflammatory demyelinating polyneuropathy (AIDP) which are diseases which impact the peripheral nervous system. It is caused by an immune response to foreign antigens in the blood, but antigenic mimicry causes the immune system to mistakenly target nerve tissue instead. Prompt removal of the foreign antigens (using plasmapheresis) can cure the disease in most patients.

Multiple Sclerosis is also an immune system failure in which the immune system targets and destroys myelin. The cause, however, is unknown. It is believed that while there may be some viral trigger which causes the disease, there are many other factors which also contribute, such as ethnicity, geography, and sex.

Since there is no identifiable antigen which needs to be removed from the bloodstream, plasmapheresis is contraindicated.

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Q: Why is plasmapheresis used to treat Guillain Barre syndrome and not Multiple sclerosis?
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