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Loop diuretics act by competing for the chloride site on the Na-K-2Cl cotransporter. Inhibiting sodium chloride reabsorption also inhibits the backleak of potassium and the generation of the lumen-positive potential. As a result, calcium excretion rises.
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How do Diuretics increase production of urine?
Not all diuretics work the same. The class of diuretics and how they work are:High ceiling loop diureticsHigh ceiling diuretics, such as Loop diuretics, inhibit the body's ability to reabsorb sodium (salt). Furosemide is an example of this type of diuretic.ThiazidesThis type of diuretic includes hydrochlorothiazide. They enhance excretion of sodium, potassium, calcium and chlorine ions, which leads to water retention in the urine.Carbonic anhydrase inhibitorsThis class of diuretics inhibit the enzyme carbonic anhydrase which is found in the proximal convoluted tubule. This results in bicarbonate and potassium retention in urine and decreased sodium absorption. Acetazolamide and methazolamide are in this class.Potassium-sparing diureticsThese do not promote the secretion of potassium into the urine, so not as much potassium is lost as in other diuretics.Calcium-sparing diureticsCalcium-sparing diuretics result in a relatively low rate of excretion of calcium.The sparing effect on calcium can be beneficial in hypocalcemia, or unwanted in hypercalcemia. The thiazides and potassium-sparing diuretics are considered to be calcium-sparing diuretics. Conversely, loop diuretics promote a significant increase calcium excretion, which can increase risk of reduced bone density.Osmotic diureticsOsmotic diuretics cause water to be retained within the proximal tubule and descending limb of loop of Henle.Low ceiling diureticsThe term "low ceiling diuretic" is used to indicate a diuretic has a rapidly flattening dose effect curve (in contrast to "high ceiling", where the relationship is close to linear).Please see the Related Link for more information.There are also foods that can act as diuretics. To learn more, see the Related Link.
What are some types of Loop diuretics?
loop diuretics loop diuretics The Potassium sparing kind. IE. Hydrochlorothiazide with triamterene or "Dyazide."
Which class of diuretic has the most rapid onset of action?
Loop diuretics have the quickest onset of action. They are called loop diuretics because they act in the loop of henle in the kidneys. The main loop diuretics are: Furosemide, Bumetanide and Torasemide
Where do diuretics get their name?
Loop diuretics, such as bumetanide (Bumex) and furosemide (Lasix), get their name from the loop-shaped part of the kidneys where they have their effect.
Can you use loop diuretics instead of thiazide diuretics in nephrogenic diabetes inspidius what will happen?
In most cases it has been noted that loop diuretics worsen the condition of the kidney in diabetes insip.
How are diuretics grouped?
Diuretics are grouped into three main categories: thiazide diuretics, loop diuretics, and potassium-sparing diuretics. Each category works by different mechanisms to increase urine output and reduce fluid retention in the body. Thiazide diuretics are commonly used for treating high blood pressure, while loop diuretics are often used for reducing excess fluid in conditions like heart failure or kidney disease. Potassium-sparing diuretics help maintain potassium levels while promoting diuresis.
Do channel blockers have any effect on kidney stone formers?
It depends on the channel/transporter being blocked. For example, it's well established that a type of diuretic called a loop diuretic (eg, furosemide) causes hypercalciuria, a fancy term for excess calcium in the urine. Loop diuretics work by blocking a sodium-potassium-chloride transporter in the kidney, and indirectly result in decreased calcium reabsorption from the urine. Because most kidney stones are made of calcium, the excess urinary calcium caused by loop diuretics can predispose people to kidney stones. By contrast, thiazide diuretics (eg, hydrochlorothiazide) commonly used to treat high blood pressure often cause hypocalciuria, which is decreased urinary calcium. Thiazides work by blocking a sodium-chloride transporter in the kidney, indirectly causing increased calcium reabsorption so less ends up in the urine. So thiazide is a reasonable medication to use for treating high blood pressure in patients prone to kidney stones. Thiazide and loop diuretics aren't technically "channel blockers", but I'm assuming you're using the term loosely. Perhaps I'm wrong though.
What is calcium build up in the body?
In order to lower your calcium levels in your body you can do a few things. Calcium is used by muscles in the human body so you can exercise and utilize some of the calcium which you have building up. You can also lower the amount of calcium you get per day and increase your fluids. Also talk to your DR. about meds that lower calcium levels such as loop diuretics, and corticosteroids.
How do Loop diuretics get their names?
They get their name from the loopshaped part of the kidneys where they have their effect
What would be a reasonable mechanism for diuretics?
Loop diuretics work by restraining the sodium-potassium-chloride cotransporter. Thiazide diuretics restrain the sodium-chloride transporter. Carbonic anhydrase inhibiting diuretics work by restraining bicarbonate transport.
What types of diuretics are available?
Loop diuretics.Thiazide diuretics.Potassium-sparing diuretics.Osmotic diuretics.Carbonic anhydrase inhibitors.Some nonprescription (over-the-counter) medicines contain diuretics
Who would be given a trousseau and what is it?
patient after thyroidectmy chronic renal failure after-treatment with loop diuretics and cytotoxic drugs
