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Fresh, pasteurised or extended shelf life milk has to be refrigerated because the processing does not remove all spoilage bacteria from the product. Refrigeration slows down the growth of spoilage bacteria and ensures that the product stays fresh longer.
UHT treated or sterilised milk has a long shelflife and does not need to be refrigerated before being opened. This is because all spoilage bacteria is destroyed during the processing (typically a very high temperature for a short time). Only once opened will spoilage bacteria contaminate the product and start growing.

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Q: Why must most milk in the US be refrigerated at all times while evaporated canned milk and milk in cardboard containers sold in Europe do not need to be refrigerated until they are open?
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