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If they are laid so that the part of the stopper that is in the bottle is able to touch the workbench, then they can either pick up contaminants that will transfer to the liquid when replacing the stopper, or they can transfer small quantities of possibly corrosive or toxic liquids, that they have picked up when the bottle was shaken or moved, to the workbench surface that can subsequently produce a safety hazard.

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Q: Why must reagents stopper be laid upside down?
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