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Why pharmacokinetics of Human Insulin does not match with Human body?
DrAshokDeshmukh
You have 'human Insulin' produced by a technique called as 'Genetic engineering'. In this you put 'Human gene' isolated from 'Human cells' into DNA of microorganism. They produce 'exact' replica of 'human insulin' and isextremelyuseful. It will never ever form antibody like Pig Insulin or Bovine insulin. But it has a dis-advantage of Pharmacokinetics. Given intro-venous or intramuscular it has half life of only about 8 minutes. So you have to give it either by continuous intro-venous drip or by repeated intro-muscular injections say every 10 to 15 minutes. For slow absorption, you have to give sub-cutaneous injection. Then it becomes too slow and you do not have a route in between. If you give subcutaneous injection of 'Human insulin', then there is immediate hyperglycemia, fallowed by hyperglycemia. So you have designers Insulin with there own disadvantages.
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∙ 11y ago
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How does the human body get insulin?
Insulin is a hormone manufactured by B-cells in the Pancreas.
Where in the human body would you find the glands that secrets insulin?
sugar/glucosePancreas is the structure in the human body that is the usual source of insulin
What is the structure in the human body that is the usual source of insulin?
Pancreas
The role of insulin in the human body is to?
Trigger body cells to take up glucose.
What Pharmacokinetics and Pharmacodynamics?
Pharmacokinetics refers to how the body processes a drug, including absorption, distribution, metabolism, and excretion. Pharmacodynamics, on the other hand, is the study of how a drug interacts with its target receptors or enzymes in the body to produce a biological response. In summary, pharmacokinetics deals with what the body does to the drug, and pharmacodynamics deals with what the drug does to the body.
What organ in the human body is responsible for secreting the hormones insulin?
The pancrease
Which is a description of pharmacokinetics?
Study of the distribution and removal of drugs in the body
What will be adverse effects of Insulin analogues in future?
Insulin was given in eleventh of January 1922 to a medical student as an extract of Islet of pancreas. Since then it has saved innumerable lives. You had two types of Insulin. One is Pig insulin and another is Bovine Insulin from extract of there respective pancreas. Pig insulin differed in amine acid sequence by one amine acid and Bovine by three amine acids from Human Insulin. Then you had something in your hand called as Insulin resistance. Normally dose of Insulin is required is 20 I.U. in A.M. and 10 I.U. in P.M. After years, in some patients dose becomes 200 I.U. in A.M. and 100 I.U. in P.M. As antibody to Insulin are formed, neutralizing the it and requiring extra dose. It means body immunity identify the difference in sequence of amine acids and replacement of a single amine acid is not tolerated by 'Immunity'. Then you have genetically engineered Insulin. It means by putting the 'Human Gene' of insulin in micro organism, you have 'exact' replica of 'Human Insulin'. This will never ever give antigen- antibody response. But it has one disadvantage and that there is immediate hyperglycemia fallowed by hypoglycemia. Means it's pharmacokinetics was not matching with blood sugar level. Because it was in the form of Insulin hexamer. So scientists designed two types of Insulin 1) Insulin Aspart in which Proline amine acid at 'B' chain is replaced by Aspartic acid. (There are few others, like Insulin Glargine.) And Insulin Lispro in which Pro-line in 'B' 28 and Lysine in 'B' 29 are interchanged. Now you are happy. Pharmacokinetics matches. But you have to pay price of this in short future. There will be antibody formation of these designer types of Insulin that they will develop antibody in due course as happened with Bovine Insulin and pig Insulin. As 'Immunity' does not tolerate change in sequence of even 'single' amine acids of 'any' body protein.
Homeostasis is illustrated in the human body by the effects of insulin on the amount of what?
Sugar in the blood.
Homeostasis is illustrated in the human body by the effects of insulin on the amount of?
glucose in the blood
Which organ in human body produces insulin?
The pancreas secretes digestive enzymes along with the enzymes insulin and glucagon.
What is the study of the movement of drugs through the body?
Pharmacokinetics is the study of drug movement through the body.
