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I am going to assume that you intend the definition of drug as "something and often an illicit substance that causes addiction, habituation, or a marked change in consciousness" (Merriam-Webster). Some drugs (Aspirin, Caffeine Claritin...) are completely fine to use in a work place.

The main reason for drug-free workplaces is because drugs alter peoples behaviors, intelligence, suggestibility, and productivity; all things that are not good things in a workplace. Also, often people on drugs are completely fixated on prolonging or reaching a high- this preoccupation can make drug users lose sight of the task at hand and seek out their drug of choice.

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