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A different cell surface protein serves to identify red blood cells as "self"; MHC 1 is not the only "self" marker. See this paper for more info.

Role of CD47 as a Marker of Self on Red Blood Cells

  1. Per-Arne Oldenborg1,
  2. Alex Zheleznyak1,
  3. Yi-Fu Fang1,
  4. Carl F. Lagenaur2,
  5. Hattie D. Gresham3 and
  6. Frederik P. Lindberg1,*
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12y ago
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14y ago

erythrocytes as with all other cells in the body have what are known as 'Self markers' or 'MHC proteins'. This tells natural killer cells not to attack them.

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Q: Why the natural killer cells do not kill erythrocytes?
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Related questions

What is the role of natural killer cells?

To kill Justin Bieber.


How a natural killer cells don't kill own or self cell because NK cells are non specific in nature?

How a natural killer cells don't kill own or self cell because NK cells are non specific in nature


What are natural killer cell?

Natural killer cells are non-phagocytic large granular lymphocytes. They kill virus-infected or cancerous cells before adaptive immune response. Natural killer cells recognise abnormal cells by its lack of cell-surface receptors such as major histocompatibility complex class 1 molecules. The natural killer cells will then secret perforin which forms pores in the cell membrane of the target cell. This results in either apoptosis or osmotic cell lysis. Natural killer cells also secrete alpha-defensins, a type of antimicrobial molecule, to directly kill bacteria by disrupting their cell walls.


What Type of T cell that directly kills virus infected body cells and some tumor cells?

Natural Killer Cells lack the membrane molecules that identify B and T cells, but they have the ability to kill a wide variety of infected body cells and certain tumor cells.


What do lymphocytes contain?

Lymphocyte contains natural killer cells (NK cells) because of the initial notion that they do not require prior activation in order to kill cells.


True or false Natural killer cells kill cancer cells?

True, NK cells are there to protect the body from any type of abnormal growth in all tissues including cancer cells.


What type of cells kill cancer cells?

I have no idea what kind of cell kills cancer cells. Why do you think i asked the question?


What are the cells called that police the body in blood and lymph to kill cancer cells and virus infected body cells?

White blood cells that directly destroy virus-infected and cancerous cells are called?


Why would you want killer t cells to be present if you have a cold?

you would want killer t cells to be present because, they kill cells that are infected by viruses, and bacterium.


How does a natural killer cell defend the body against infection?

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T Lymphocytes are responsible for?

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Can all white blood cells attack any kind of pathogen?

No, the white blood cells are divided into many types of specialized cells. The Macrophages, Granulocytes, Natural Killer cells and Dendritic (Lagerhans) cells are part of the immuno response system's first line of defense: Macrophages kill any type of pathogens they recognize as not welcome, while the Neutrophile Granulocytes are experts in bacteria killing. Dendritic cells alert the adaptive immuno response system such as T-cells. Cytotoxic T-cells then kill tissue cells infected by pathogens, and so does Natural Killer cells (but does not touch the pathogens themselves). They do not have to be activated first, but are able to find infected/sick cells by themselves, which makes them effective cancer-killers. Also, by killing infected cells they prevent growth and proliferation of more pathogens in the body. Regulatory-T-cells (suppressor cells) and T-Helper cells does not kill pathogens themselves but regulate the rest of the white blood cells.