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Because exposing your immune system to everything under the sun in one hit may be a bit too much for it to handle at once. If you want a good immune response, give vaccines over time - it's like you running three marathons at once: you're likely to perform better on them if they're not all in the one hit.

Some vaccines (flu vaccines) are different each year, depending on what strains are getting around.

Some vaccines are live - not dangerous, that bit's been bred out of them, but if you give these ones all together, they might ruin the chances of each of them actually having a response, because they might battle it out between each other.

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Q: Why vaccines are given periodically and not altogether?
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