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The manned missions to the Moon had "consumables" that were used up and could not be replaced. One was food, but another was more crucial: lithium hydroxide used to filter carbon dioxide from the recirculated air. Otherwise it would build up no matter how much oxygen was added.

Long-term missions should be able to use energy (natural or generated) to produce food and clean recycled water and air. Green plants would be one way to provide food and remove CO2, but these require a lot of space for even a small crew.

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Q: Why would a closed ecology be essential in a spaceship designed for a long voyage when it was not essential for the voyage to the moon and back?
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