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Enzymes are biologically active molecules with specific "active sites", a good analogy is a key and its characteristic notches. If the factor modifies the enzyme's shape then the locations of the enzyme's "active sites" (notches, so to speak) may also be changed, or the sites may be deleteriously affected. Thus the functionality of the enzyme is impaired.

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Q: Why would a factor that changes the shape of an enzyme prevent it from functioning?
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