bcoz of coating. And for transport
behnchood
what is the tblet hardness,what is its unit ,we aply hydraulic pressure on tablet compression mchine but in result we gain hardness on tablet,how the pressure is converted into hardness unit. Friability refers to the ability of the compressed tablet to avoid fracture and breaking apart during transport.
Tablet whiskering refers to the formation of fine, hair-like lines on the surface of a tablet. It is typically a cosmetic issue caused by the drying process during tablet manufacturing and does not affect the efficacy or safety of the medication.
The Ability to crumble of sand is known as friability
friability F=I-F.100/I where I =Iinitial weight of tablets , F = weight after friability. Normal limit less than 1%.
clinicik test
NMT 2%
Friability erythema and erosion in the stomach means that the stomach is red and there is lose of the lining. It can occur from tiny sores in the stomach.
Granularity, friability, and erythema in the antrum are all endoscopic findings. If these are found a patient is usually diagnosed with Gastroduodenal Crohn's disease
The friabilty tester measures how much weight does the drug loses after a certain number of drops. Tablets are dropped from 6 inches at 25 rpm for 100 times. As for drugs with a film coating, they are dropped for 500 times. If the tablet mass is less than 650mg, only tablets which weight 6.5g should be selected for the friability test. For tablets which are heavier than 650mg, 10 tablets should be randomly selected for this test. If the weight loss is larger than 1%, the drug may require reformulation. The pressure used to form the drug may need to be increased ad beveled edge tooling may be used to produce them.
Yes
Friability testing is done on all pharmaceutical tablets. The testing involves absorption rates, crushing levels and powderization, and enteric capability.