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What is tablet hardness and friability?
what is the tblet hardness,what is its unit ,we aply hydraulic pressure on tablet compression mchine but in result we gain hardness on tablet,how the pressure is converted into hardness unit. Friability refers to the ability of the compressed tablet to avoid fracture and breaking apart during transport.
What is tablet whiskering?
Tablet whiskering refers to the formation of fine, hair-like lines on the surface of a tablet. It is typically a cosmetic issue caused by the drying process during tablet manufacturing and does not affect the efficacy or safety of the medication.
What is principal of tablet hardness and friability?
The principle of tablet hardness is to measure the tablets' resistance to breaking or chipping under pressure, which is important for assessing their mechanical strength. The principle of tablet friability is to measure the tablets' tendency to break or crumble when subjected to mechanical stress during handling or storage, serving as an indicator of their robustness and quality. Both tests are crucial in assessing the physical properties of tablets for formulation and manufacturing.
What is the formula to calculate friability?
friability F=I-F.100/I where I =Iinitial weight of tablets , F = weight after friability. Normal limit less than 1%.
What is sands friability?
Sands friability refers to how easily sand can be broken down into smaller particles or dust when subject to pressure or friction. Sands with lower friability will be more resistant to breaking down, while sands with higher friability will be more prone to fragmentation. This property can impact the handling, transportation, and stability of sand materials in various applications.
How friability is measured?
Friability is typically measured using a friability tester, which consists of a rotating drum that tumbles a sample of tablets or granules for a specified time. After tumbling, the sample is weighed to determine the weight loss due to abrasion and breakage, which is expressed as a percentage. This percentage indicates the friability of the tablets or granules.
What tablet is dropped into a test tube of urine to test glucose?
A glucose tablet is usually dropped into a test tube of urine to test for glucose. The tablet contains a substance that reacts with glucose in the urine, causing a color change that indicates the presence of glucose.
What is the USP limits for friability?
NMT 2%
What is friability erythema and erosion in the stomach?
Friability erythema and erosion in the stomach means that the stomach is red and there is lose of the lining. It can occur from tiny sores in the stomach.
How do you use the friability tester for drugs?
The friabilty tester measures how much weight does the drug loses after a certain number of drops. Tablets are dropped from 6 inches at 25 rpm for 100 times. As for drugs with a film coating, they are dropped for 500 times. If the tablet mass is less than 650mg, only tablets which weight 6.5g should be selected for the friability test. For tablets which are heavier than 650mg, 10 tablets should be randomly selected for this test. If the weight loss is larger than 1%, the drug may require reformulation. The pressure used to form the drug may need to be increased ad beveled edge tooling may be used to produce them.
Why is the friability tester set at 100 revolutions?
The friability tester is typically set at 100 revolutions as this is the standard requirement in pharmacopeial guidelines for testing the friability of tablets. This number of revolutions is commonly used to simulate the handling and transportation stress that tablets may undergo during manufacturing and distribution.
Can you get the impossible test space on Android tablet?
Yes
