Will Seroquel show up as positive on the Tricyclic Antidepressant panel of a drug test?

Answer 1

As part of an ongoing treatment study of co-occurring bipolar mania and cannabis abuse in adolescents, we obtained bi-monthly urine toxicology screens using the Status DS™ immunoassay. It was noted that the first five subjects initially tested negative for tricylcic antidepressants (TCAs) but all five tested positive after being treated with topiramate or placebo and quetiapine. All of the patients denied using TCAs, but were forthcoming regarding their drug use. A quetiapine trough blood level was also obtained on the same morning that the urine toxicology screens were performed and the results paralleled the TCA toxicology findings, i.e., when subjects showed quetiapine in their serum (5.1 to 85 ng/ml), they tested positive for TCAs. However, when two of the subjects were non-adherent to their medications and their quetiapine levels were undetectable, their toxicology screens were negative for TCAs. After these two patients were encouraged to take their medications and had detectable quetiapine levels, they once again tested positive for TCIt looks like Seroquel will show up as a positive for TCA panel.

Answer 2

There is no evidence to show that Seroquel (quetiapine) will show up on a drug test as THC. Always be sure to tell the person conducting the drug test what medications you are on, just in case.