Yes. When hemoglobin is broken down into heme and globin, the heme sends bilirubin to your liver. If your liver isn't functioning properly it won't be able to secrete it into your intestines.
When the liver is damaged as with hepatitis it is no longer able to metabolize the bilirubin in the blood and causes jaundice which is a yellowing of the whites of the eyes and skin.
Indirect bilirubin travels through the blood stream to the liver. Indirect bilirubin does not dissolve in water until it reaches the liver.
The liver. The liver is damaged. The yellow color of the skin indicates that the liver can no longer conjugate bilirubin properly.
From the glossary of medical terms the answer is: BILIRUBIN
Damage to the liver or the Kidneys may cause a build up of Bilirubin.
A total bilirubin of 9 is fine. Some hospitals state it should be under 12, some state it should be under 17. Bilirubin blood test levels are one of those things where "lower is better". (Bilirubin is a byproduct which you liver is supposed to excrete in bile, which is then excreted via your digestive system. If your liver is not excreting bilirubin in bile, your blood bilirubin level increases, showing that your liver isn't quite right.)
When the erythrocytes are destroyed, haemoglobin breaks down, the heme part of it goes through a series of transformation: Heme → biliverdin (green pigment) biliverdin → bilirubin (orange-yellow pigment) Bilirubin + blood albumin → bound bilirubin (in peripheral blood) Bound bilirubin + glucuronic acid → conjugated bilirubin. (in liver) Conjugated bilirubin + intestinal bacteria → several pigments, including - stercobolin (orange-brown pigment, excreted in feces) and - urobilinogen (reabsorbed into bile/blood, finally excreted in urine)
In addition to urea, the liver produces bilirubin as a result of the recycling of red blood cells. The bilirubin is excreted through bile.
increase levels of bilirubin in blood due to increased production as in rapid destruction of red blood cells. more commonly it is due to decreased elimination of bilirubin because of liver disease.
Before birth, an infant gets rid of bilirubin through the mother's blood and liver systems. After birth, the baby's liver has to take over processing bilirubin on its own.
Indirect bilirubin
Blood tests alone cannot "confirm" cirrhosis of the liver - final confirmation must be done by a liver biopsy. However the usual blood "indicators" of liver cirrhosis which are useful to know about (and usually all combined in a package known as "liver function blood tests") are an elevated AST and ALT (liver enzymes, which leak from hepatocytes when the cells are damaged), high bilirubin (directly correlates to how itchy you are) and high GGT, a marker for alcoholic cirrhosis.