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It can.

Higher urine concentrations of ranitidine can trigger a false positive. In the study I'll attach in the "related links" section below it was seen in people testing the first two voids after taking the drug and only with the monoclonal EMIT d.a.u. amphetamine/methamphetamine immunoassay (ME).

This did not happen with the polyclonal EMIT d.a.u. amphetamine or TDx amphetamine/methamphetamine II assays.

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Q: Will ranitidine make you fail a drug test for methamphetamine?
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