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Natural disasters can wipe out Humans, or asteroids which are big and close to Earth. Or the apocalypse, if you're christian. Or the grey goo, a situation which nano bots reproduce unlimitedly. Or maybe by smoking, not everyone smokes but a lot of people die by 2nd hand smoking. So smoking is bad for everyone. Or by Swine Flu and other diseases and war. Or by accidents.

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12y ago
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Q: With what causes can it wipe out human civilization.?
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