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It depends on the context. If melanin was essential to good health, and a lack of it produces serious health problems then it could be considered a defect (assuming the lack of melanin was due to genetics). Having a total lack of it when the vast majority of creatures have it would certainly qualify as an unusual condition but just having less of it than others is a little too vague to be considered a defect without understanding the context. Like any 'trait' less of something may be beneficial in some environments but more of it may be beneficial in others. ----------------------------------- Albinism (complete or partial loss of melanin) is genetic.

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Q: Would having less melinin be considered a genetic defect?
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