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Acquired platelet function defects are diseases or conditions that cause the blood elements needed for blood clotting (platelets) to not work properly. The term "acquired" means these diseases or conditions are not inherited, but instead develop independently in a person.
Alternative NamesAcquired qualitative platelet disorders; Acquired disorders of platelet function
Causes, incidence, and risk factorsWith platelet disorders, there may be too many or too few platelets, or platelets that do not function well. Any platelet disorder affects blood clotting.
These disorders can be caused by diseases that are present at birth (congenital), or they may develop because of another disease or condition. In many cases, the platelet count may be normal or even high, but there will be evidence of a bleeding disorder.
Disorders that can cause problems in platelet function include:
Other causes include:
- Kidney (renal) failure
- Multiple myeloma
- Medications such as aspirin, ibuprofen and other anti-inflammatory drugs, penicillins, phenothiazines, and prednisone (after long-term use)
- Abnormal color of urine (blood in the urine)
- Abnormal menstrual periods
- Heavy menstrual periods
- Prolonged menstrual bleeding (more than 5 days per menstrual period)
- Abnormal vaginal bleeding
- Bleeding under the skin or in the muscles (soft tissues)
- Gastrointestinal bleeding
- Bloody, dark black, or tarry bowel movements
- Vomiting bloodor vomiting material that resembles coffee grounds
- Nosebleeds
- Prolonged bleeding, easy bruising
- Skin rash
- Bruises
- Pinpoint red spots (petechiae)
Treatment is aimed at the cause of the problem.
- Bone marrow disorders (which have abnormally high numbers of platelets) are treated with platelet transfusions or by removing platelets from the blood and replacing them with donated platelets (plateletpheresis)
- Kidney failure is treated with dialysis or a drug called ddAVP
- Platelet problems caused by medication are treated by stopping the medication
Treating the cause of the problem usually corrects the defect.
Complications- Prolonged bleeding
- Severe anemia
Call your health care provider:
- If you have bleeding and do not know the cause
- If your symptoms get worse or do not improve after you are treated for an acquired platelet function defect
Using medications carefully can reduce the risk of drug-related acquired platelet function defects. Treating other disorders may also reduce the risk. Some cases are not preventable.
ReferencesMcMillan R. Hemorrhagic disorders: Abnormalities of platelet and vascular function. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 179.
What else can I help you with?
What is the function of the tooth cavity?
This a defect, an infection and has no function.
What is the function of cavity of a tooth?
This a defect, an infection and has no function.
What does underlying pathologic defect mean?
An underlying pathologic defect refers to a fundamental abnormality or dysfunction in the body's structure or function that contributes to a disease or health condition. This defect can be genetic, developmental, or acquired, and it often sets the stage for the manifestation of symptoms or complications. Identifying the underlying defect is crucial for diagnosis and treatment, as it helps healthcare providers target the root cause rather than just addressing the symptoms.
Are Coagulation defects are always congenital?
No. A coagulation defect occurs by heredity and acquired means.
A disease that involves a defect in the cell-mediated immunity system?
AIDS- acquired immune deficiency syndrome
What is the difference between a congenital disorder and a birth defect?
Congenital diseases are passed genetically from a parent to an off-spring .These are acquired by birth.Acquired diseases are not passed genetically .they are acquired after birth.
Congenital platelet function defects?
DefinitionCongenital platelet function defects are problems with platelets, one of the blood elements needed for normal blood clotting. Congenital means present from birth.Alternative NamesPlatelet storage pool disorder; Glanzmann's thrombasthenia; Bernard-Soulier syndrome; Platelet function defects - congenitalCauses, incidence, and risk factorsPlatelets are elements in the blood that help form clots. Congenital platelet function defects are bleeding disorders that cause reduced platelet function, even though there are normal platelet counts.People with these disorders usually have a family history of a bleeding disorder that causes prolonged bleeding after minor cuts or surgery, or easy bruising.Bernard-Soulier syndrome occurs when platelets lack a substance that sticks to the walls of blood vessels. This disorder may cause severe bleeding.Glanzmann's thrombasthenia is a condition caused by the lack of a protein required for platelets to clump together. This disorder may also cause severe bleeding.Platelet storage pool disorder is a mild defect that causes bruising. It is caused by faulty storage of substances inside platelets. These substances are usually released to help platelets function properly.SymptomsAbnormal menstrual periodsBleeding during and after surgeryBleeding gumsEasy bruisingNosebleeds (epistaxis)Prolonged bleeding with small injuriesSigns and testsThe following tests may be used to diagnose this condition:Bleeding timeCBCPlatelet aggregation testPT, PTTYou may need other tests. Your relatives may need to be tested.TreatmentThere is no specific treatment for these disorders.People with bleeding disorders should avoid taking aspirin and nonsteroidal anti-inflammatory drugs (such as ibuprofen and naproxen) because they are known to affect blood clotting. Patients who have severe bleeding may need platelet transfusions.Expectations (prognosis)Treatment can usually control the bleeding. However, congenital platelet function defects are life-long conditions. There is no cure. Patients should take precautions to avoid bleeding.ComplicationsSevere bleedingIron deficiency anemia in menstruating womenCalling your health care providerCall your health care provider if:You have bleeding or bruising and do not know the causeBleeding does not respond to the usual method of controlPreventionA blood test can detect the gene responsible for the platelet defect. Genetic counseling may be helpful to couples with a family history of a congenital platelet function defect who are planning to have children in the future.ReferencesMcMillan R. Hemorrhagic disorders: Abnormalities of platelet and vascular function. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 179.
The disease cystic fibrosis involves a genetic defect that interferes with the packaging and shipping of cell products This defect directly inhibits the function of which organelle?
Golgi apparatus
This results from a defect in membrane proteins that normally function in chloride ion transport?
Cystic Fibrosis
Which metric do you use to analyze the ratio of problems in a program as compared to a unit of measure such as function points or lines of code?
Metrics can be used to measure defects. For example, there are several different types such as defect category, closed defect distribution, and defect removal efficiency.
Dose red wine have horse manure in it?
No, it does not. However, some wines from Burgundy have a "wet horse blanket" characteristic. Appreciating what may be a defect appears to be an acquired taste.
What is hemorrhage defect?
Best term is clotting defect and it is the term used to genericly refer to all conditions where one of th multiple clotting factors of the blood including platelet anomalies is present in an individual yielding to bleeding.
