Ascites

Answer 1

Definition

Ascites is excess fluid in the space between the tissues lining the abdomen and abdominal organs (the peritoneal cavity).

Alternative Names

Portal hypertension - ascites

Causes, incidence, and risk factors

A person with ascites usually has severe liver disease. Ascites due to liver disease is caused by high pressure in the blood vessels of the liver (portal hypertension) and low albumin levels.

Disorders that may be associated with ascites include:

• Cirrhosis and any illness that leads to it
• Clots in the veins of the liver (portal vein thrombosis)
• Colon cancer
• Congestive heart failure
• Constrictive pericarditis
• Hepatitis
• Infections such as tuberculosis
• Liver cancer
• Nephrotic syndrome
• Ovarian cancer, endometrial cancer
• Pancreatitis
• Pancreatic cancer
• Protein-losing enteropathy

Kidney dialysis may also be associated with ascites.

Signs and tests

A physical examination may reveal a swollen abdomen, or belly.

Test to evaluate the liver may be done. This may include:

• Kidney function tests
• Creatinine and electrolytes
• Urinalysis
• 24-hour urine collection

Paracentesis or abdominal tap may be performed. This procedure involves using a thin needle to pull fluid from the abdomen. The fluid is tested in various ways to determine the cause of ascites.

Treatment

The condition that causes ascites will be treated, if possible.

Treatment may include:

• Diuretics, or "water pills," to help remove the fluid; usually, spironolactone (Aldactone) is used at first, and then furosemide (Lasix) will be added
• Antibiotics, if an infection develops
• Limiting salt in the diet (no more than 1,500 mg/day of sodium)
• Avoiding drinking alcohol

Procedures used for ascites that do not respond to medical treatment include:

• Placing a tube into the area to remove large volumes of fluid (called a large volume paracentesis)
• Transjugular intrahepatic portosystemic shunt (TIPS), which helps reroute blood around the liver

As patients develop end-stage liver disease, and the ascites no longer respond to treatment, liver transplantation becomes necessary.

Complications

• Spontaneous bacterial peritonitis (a life-threatening infection of the ascites fluid)
• Hepatorenal syndrome (kidney failure)
• Weight loss and protein malnutrition
• Mental confusion, change in the level of alertness, or coma (hepatic encephalopathy)
• Other complications of liver cirrhosis

Calling your health care provider

Anyone who has ascites and develops new abdominal pain and fever should contact their health care provider immediately.

References

Runyon BA; AASLD Practice Guidelines Committee. Management of adult patients with ascites due to cirrhosis: an update. Hepatology. 2009;49(6):2087-2107.

Answer 2

Definition

Ascites is excess fluid in the space between the tissues lining the abdomen and abdominal organs (the peritoneal cavity).

See also:

• Alcoholic liver disease
• Cirrhosis

Alternative Names

Portal hypertension - ascites

Causes, incidence, and risk factors

A person with ascites usually has severe liver disease. Ascites due to liver disease is caused by high pressure in the blood vessels of the liver (portal hypertension) and low albumin levels.

Cirrhosisand any illness that leads to it is a common cause of ascites. Long-term infections with hepatitis C or B and long-term alcohol abuse are two of the most common causes of cirrhosis.

People with colon cancer, ovarian cancer, endometrial cancer, pancreatic cancer, and liver cancer may develop ascites. Other conditions which may lead to this problem include:

Disorders that may be associated with ascites include:

• Clots in the veins of the liver (portal vein thrombosis)
• Congestive heart failure
• Pancreatitis
• Thickening and scarring of the sac like covering of the heart

Kidney dialysis may also be associated with ascites.

Symptoms

When just a small amount of fluid has collected in the belly, there may be no symptoms. Symptoms often develop slowly or suddenly, but a rapid buildup of fluid and symptoms may occur with some causes of ascites.

As more fluid collects, abdominal pain and bloating may occur. When a large amount of ascites is present shortness of breath may develop also.

Signs and tests

A physical examination may reveal a swollen abdomen, or belly.

Test to evaluate the liver may be done, including:

• 24-hour urine collection
• Creatinine and electrolytes
• Kidney function tests
• Liver enzyme, bilirubin, coagulation, and serum protein tests
• Urinalysis

Paracentesis or abdominal tap may be performed. This procedure involves using a thin needle to pull fluid from the abdomen. The fluid is tested in various ways to determine the cause of ascites.

Treatment

The condition that causes ascites will be treated, if possible.

Treatment may include:

• Diuretics, or "water pills," to help remove the fluid; usually, spironolactone (Aldactone) is used first, and then furosemide (Lasix) will be added
• Antibiotics, if an infection develops
• Limiting salt in the diet (no more than 1,500 mg/day of sodium)
• Avoiding drinking alcohol

Procedures used for ascites that do not respond to medical treatment include:

• Placing a tube into the area to remove large volumes of fluid (called a large volume paracentesis)
• Transjugular intrahepatic portosystemic shunt (TIPS), which helps reroute blood around the liver

Patients who develop end-stage liver disease, and whose ascites no longer respond to treatment will need a liver transplant.

Complications

• Spontaneous bacterial peritonitis (a life-threatening infection of the ascites fluid)
• Hepatorenal syndrome (kidney failure)
• Weight loss and protein malnutrition
• Mental confusion, change in the level of alertness, or coma (hepatic encephalopathy)
• Other complications of liver cirrhosis

Calling your health care provider

Anyone who has ascites and develops new abdominal pain and fever should contact their health care provider immediately.

References

Runyon BA; AASLD Practice Guidelines Committee. Management of adult patients with ascites due to cirrhosis: an update. Hepatology. 2009;49(6):2087-2107.

Mehta G, Rothstein KD. Health maintenance issues in cirrhosis.Med Clin North Am. 2009;93:901-915.

Garcia-Tsao G. Cirrhosis and its sequelae. In: Goldman L, Ausiello D, eds.Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 156.

Reviewed By

Review Date: 10/16/2011

David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc. and George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California.