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The CPK isoenzymes test measures the different forms of creatine phosphokinase (CPK) in the blood. CPK is an enzyme found mainly in the heart, brain, and skeletal muscle.
See also: Creatine phosphokinase test
Alternative NamesCreatine phosphokinase - isoenzymes; Creatine kinase - isoenzymes; CK - isoenzymes
How the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.
Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
If you are in the hospital, this test may be repeated over 2 or 3 days. A significant rise or fall in the total CPK or CPK isoenzymes can help your health care provider diagnosis certain conditions.
How to prepare for the testUsually, no special preparation is necessary.
Tell your doctor about all the medications you are taking. Certain medications can interfere with test results. Drugs that can increase CPK measurements include the following:
- Amphotericin B
- Ampicillin
- Some anesthetics
- Anticoagulants
- Aspirin
- Clofibrate
- Dexamethasone
- Furosemide
- Morphine
- Alcohol
- Cocaine
When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedThis test is done if a CPK test reveals that your total CPK level is elevated. CPK isoenzyme testing can help pinpoint the exact soure of the damaged tissue.
CPK is made of three slightly different substances:
- CPK-1 (also called CPK-BB) is found mostly in the brain and lungs
- CPK-2 (also called CPK-MB) is found mostly in the heart
- CPK-3 (also called CPK-MM) is found mostly in skeletal muscle
Higher-than-normal CPK-1 levels:
Because CPK-1 is found mostly in the brain and lungs, injury to either of these areas can increase CPK-1 levels. Increased CPK-1 levels may be due to:
- Brain cancer
- Brain injury(due to injury, stroke, or bleeding in the brain)
- Electroconvulsive therapy
- Pulmonary infarction
- Seizure
Higher-than-normal CPK-2 levels:
CPK-2 levels rise 3 - 6 hours after a heart attack. If there is no further heart muscle damage, the level peaks at 12 - 24 hours and returns to normal 12 - 48 hours after tissue death.
Increased CPK-2 levels may also be due to:
- Electrical injuries
- Heart defibrillation (purposeful shocking of the heart by medical personnel)
- Heart injury (for instance, from a car accident)
- Inflammation of the heart muscle usually due to a virus (myocarditis)
- Open heart surgery
CPK-2 levels do NOT usually rise with chest pain caused by angina, pulmonary embolism (blood clot in the lung), or congestive heart failure.
Higher-than-normal CPK-3 levels are usually a sign of muscle injury or muscle stress and may be due to:
- Crush injuries
- Muscle damage due to drugs or being immobile for a long time (rhabdomyolysis)
- Muscular dystrophy
- Myositis(skeletal muscle inflammation)
- Receiving many intramuscular injections
- Recent nerve and muscle function testing (electromyography)
- Recent seizures
- Recent surgery
- Strenuous exercise
Factors that can affect test results include cardiac catheterization, intramuscular injections, recent surgery, and vigorous and prolonged exercise or immobilization.
Isoenzyme testing for specific conditions is about 90% accurate.
ReferencesAnderson JL. ST segment elevation acute myocardial infarction and complications of myocardial infarction. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 72.
Barohn RJ. Muscle diseases. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 447.
Wiki User
∙ 13y ago
Wiki User
∙ 12y agoThe CPK isoenzymes test measures the different forms of creatine phosphokinase (CPK) in the blood. CPK is an enzyme found mainly in the heart, brain, and skeletal muscle.
See also: Creatine phosphokinase test
Alternative NamesCreatine phosphokinase - isoenzymes; Creatine kinase - isoenzymes; CK - isoenzymes
How the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.
Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
If you are in the hospital, this test may be repeated over 2 or 3 days. A significant rise or fall in the total CPK or CPK isoenzymes can help your health care provider diagnosis certain conditions.
How to prepare for the testUsually, no special preparation is necessary.
Tell your doctor about all the medications you are taking. Certain medications can interfere with test results. Drugs that can increase CPK measurements include the following:
- Alcohol
- Amphotericin B
- Certain anesthetics
- Cocaine
- Fibrate drugs
- Statins
- Steroids such as dexamethasone
This list is not all-inclusive.
How the test will feelWhen the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedThis test is done if a CPK test reveals that your total CPK level is elevated. CPK isoenzyme testing can help pinpoint the exact source of the damaged tissue.
CPK is made of three slightly different substances:
- CPK-1 (also called CPK-BB) is found mostly in the brain and lungs
- CPK-2 (also called CPK-MB) is found mostly in the heart
- CPK-3 (also called CPK-MM) is found mostly in skeletal muscle
Higher-than-normal CPK-1 levels:
Because CPK-1 is found mostly in the brain and lungs, injury to either of these areas can increase CPK-1 levels. Increased CPK-1 levels may be due to:
- Brain cancer
- Brain injury(due to injury, stroke, or bleeding in the brain)
- Electroconvulsive therapy
- Pulmonary infarction
- Seizure
Higher-than-normal CPK-2 levels:
CPK-2 levels rise 3 - 6 hours after a heart attack. If there is no further heart muscle damage, the level peaks at 12 - 24 hours and returns to normal 12 - 48 hours after tissue death.
Increased CPK-2 levels may also be due to:
- Electrical injuries
- Heart defibrillation (purposeful shocking of the heart by medical personnel)
- Heart injury (for instance, from a car accident)
- Inflammation of the heart muscle usually due to a virus (myocarditis)
- Open heart surgery
CPK-2 levels do NOT usually rise with chest pain caused by angina, pulmonary embolism (blood clot in the lung), or congestive heart failure.
Higher-than-normal CPK-3 levels are usually a sign of muscle injury or muscle stress and may be due to:
- Crush injuries
- Muscle damage due to drugs or being immobile for a long time (rhabdomyolysis)
- Muscular dystrophy
- Myositis(skeletal muscle inflammation)
- Receiving many intramuscular injections
- Recent nerve and muscle function testing (electromyography)
- Recent seizures
- Recent surgery
- Strenuous exercise
Factors that can affect test results include cardiac catheterization, intramuscular injections, recent surgery, and vigorous and prolonged exercise or immobilization.
Isoenzyme testing for specific conditions is about 90% accurate.
ReferencesAnderson JL. ST segment elevation acute myocardial infarction and complications of myocardial infarction. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 72.
Barohn RJ. Muscle diseases. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 447.
Cannon CP, Lee TH. Approach to the patient with chest pain. In: Libby P, Bonow RO, Mann DL, Zipes DP, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 49.
Reviewed ByReview Date: 02/17/2011
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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What color test tube is Cpk?
Green
What is CPK chemistry blood test?
CPK is an enzyme called creatine kinase. It is mostly found in the heart, brain and muscle tissues. When there is trauma or damage to those tissues the enzyme is released into the bloodstream where it shows up as an elevated CPK on bloodwork. CPK is often elevated after a heavy workout or any type of crushing injury. The CPK is often elevated soon after a heart attack. Some muscle degenerating diseases also can be detected by a constantly high CPK level. It is up to your physician to determine the significance of the result. CPK can further be broken down into specific sub-enzymes called iso-enzymes. One is heart specific, one is muscle specific and so on. So if a CPK level is elevated and the cause is not known, testing for iso-enzymes can indicate what body tissue the CPK is coming from.
What color tube is used for cpk?
Mint
What is a normal blood creatinine phophokinase level?
A normal creatine phosphokinase (CPK) level is anywhere from 10 to 120 micrograms per liter (mg/L). CPK is released when a muscle is damaged and can show whether a person has had a heart attack.
What color tube do you use to draw cpk?
It depends on your lab, but for most, it is a mint green tube and you only need to draw 1
What color test tube is Cpk?
Green
What does cpk mean in a blood test?
creatine phosphate kinase. it increases in heart disease & muscular disease.
What is CPK chemistry blood test?
CPK is an enzyme called creatine kinase. It is mostly found in the heart, brain and muscle tissues. When there is trauma or damage to those tissues the enzyme is released into the bloodstream where it shows up as an elevated CPK on bloodwork. CPK is often elevated after a heavy workout or any type of crushing injury. The CPK is often elevated soon after a heart attack. Some muscle degenerating diseases also can be detected by a constantly high CPK level. It is up to your physician to determine the significance of the result. CPK can further be broken down into specific sub-enzymes called iso-enzymes. One is heart specific, one is muscle specific and so on. So if a CPK level is elevated and the cause is not known, testing for iso-enzymes can indicate what body tissue the CPK is coming from.
List of abbreviation for 'Cpk'?
Cpk = Cp (Process Capability) + p (katayori) Japanese for deviation. Cpk = Deviation of process capability
What is the significance of a slightly elevated creatine kinase blood test presumed not cardiac related?
cpk enzymes are found in cardiac muscle, skeletal muscle and the brain, cpk will be elevated 10 to 25 times the normal level following a myocardial infarction, they will also be elevated after a trauma to skeletal muscle and in progressive muscular dystrophy, cpk can be elevated after strenuous exercise.
What does the medical abbreviation CPK mean?
CPK means creatine phosphokinase. It's sometimes abbreviated CK. CPK testing is often used to evaluate chest pain.
What is the definition of Cp and Cpk in Statistical process control?
Cp is the capability of a process and Cpk is the actual capability of a part running in the process. The only way Cp = Cpk is if the process mean is exactly centered which is seldom the case in manufacturing. Therefore, Cp > or = to Cpk.
What is the market cap for Chesapeake Utilities Corporation CPK?
As of July 2014, the market cap for Chesapeake Utilities Corporation (CPK) is $663,357,115.20.
What causes cpk level?
When the total CPK level is very high, it usually means there has been injury or stress to muscle tissue, the heart, or the brain. Muscle tissue injury is most likely. When a muscle is damaged, CPK leaks into the bloodstream.
What causes elevated CPK?
When the total CPK level is very high, it usually means there has been injury or stress to muscle tissue, the heart, or the brain. Muscle tissue injury is most likely. When a muscle is damaged, CPK leaks into the bloodstream.
What cpk stands for in blood test?
what is cpk. How is it increased by crestor? what is crestor? CPK, also known as CK and Creatine phosphokinase, is more formally called Creatine Kinase. This is a test performed to determine whether or not the individual has had a heart attack. Higher levels of CK indicate injured muscles or heart cells. Very heavy exercise, excessive drinking, injury to person via car accident or fall or etc., and drugs that lower cholesterol can all increase the level of CK in the blood. CK levels can be increased by drugs such as Crestor because it damages muscle. Crestor is a cholesterol-lowering medication or statin.
What causes elevated CPK level?
When the total CPK level is very high, it usually means there has been injury or stress to muscle tissue, the heart, or the brain. Muscle tissue injury is most likely. When a muscle is damaged, CPK leaks into the bloodstream.
