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Antidiuretic hormone (ADH), or vasopressin, is a substance produced naturally by the hypothalamus and released by the pituitary gland. The hormone controls the amount of water your body removes.
Ectopic ADH secretion is the release of ADH from an abnormal location within the body. Ectopic means "out of place."
Alternative NamesSIADH; Syndrome of inappropriate antidiuretic hormone secretion
Causes, incidence, and risk factorsThe most common cause of ectopic ADH secretion is cancer. Certain lung cancers, as well as some head and neck tumors, are the most common cancers that cause this problem. In rare cases, many other tumors may cause ectopic ADH secretion.
See also:
SymptomsThe abnormal release of ADH makes it harder for the body to remove water. Fluid builds up in the body. Low blood sodium levels (hyponatremia) can occur.
Often, there are no symptoms from low sodium levels. However, changes in mental status and even seizures may occur.
TreatmentTreatment is aimed at removing the cause of the problem (for example, surgery to remove a tumor producing ADH).
Limiting fluid intake is another common treatment. This helps prevent excess water from building up in the body.
Patients in the hospital with ectopic ADH that does not respond to other treatments may be given tolvaptan by mouth (orally) and conivaptan through a vein (intravenous). These treatments block the effects of ADH.
ReferencesLin M, Liu SJ, Lim IT. Disorders of water imbalance. Emerg Med Clin North Am. 2005;23(3):749-770.
Gagel RF. Endocrine manifestations of tumors: "ectopic" hormone production. In: Goldman L, Ausiello D, eds. Cecil Medicine. Philadelphia, PA: Saunders; 2007:chap 188.
Wiki User
∙ 13y ago
Wiki User
∙ 12y agoEctopic ADH secretion is the release of Antidiuretic hormone (ADH), or vasopressin, from an abnormal place in the body. ADH is a substance produced naturally by the hypothalamus and released by the pituitary gland. This hormone controls the amount of water your body removes.
Ectopic means "out of place."
Alternative NamesSIADH; Syndrome of inappropriate antidiuretic hormone secretion
Causes, incidence, and risk factorsThe most common cause of ectopic ADH secretion is cancer. Certain lung cancers, as well as some head and neck tumors, are the most common cancers that cause this problem. In rare cases, many other tumors may cause ectopic ADH secretion.
See also:
SymptomsThe abnormal release of ADH makes it harder for the body to remove water. Fluid builds up in the body. Low blood sodium levels (hyponatremia) can occur.
Often, there are no symptoms from low sodium levels. However, changes in mental status and even seizures may occur.
TreatmentTreatment is aimed at removing the cause of the problem (for example, surgery to remove a tumor producing ADH).
Limiting fluid intake is another common treatment. This helps prevent excess water from building up in the body.
Patients in the hospital with ectopic ADH that does not respond to other treatments may be given tolvaptan by mouth (orally) and conivaptan through a vein (intravenous). These treatments block the effects of ADH.
ReferencesStewart PM, Krone NP. The adrenal cortex. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 15.
Reviewed ByReview Date: 12/11/2011
Nancy J. Rennert, MD, Chief of Endocrinology & Diabetes, Norwalk Hospital, Associate Clinical Professor of Medicine, Yale University School of Medicine, New Haven, CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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Alcohol inhibits the secretion of what hormone?
antidiuretic hormone(ADH)
What stimulates adh secretion from the posterior pituitary?
increased plasma osmolality
What is the disease caused due to failure of ADH secretion?
Diabetes insipidus
What does the posterior pituitary gland control?
ADH secretion and oxytocim release
What medical condition would describe an inadequate secretion of ADH?
Diabetes insipidus
What causes hypo-secretion of ADH?
diabetes insipidus
What are the effects of hyper secretion of ADH in urine quantity and component?
ADH is short for Anti Diuretic Hormone and it prevents excess water loss. As such, a hyper-secretion of ADH will result in less urine by volume, and the urine will have a lower concentration of water. Conversely, it will have a higher concentration of solutes (Sodium, Potassium, Urea, etc.)
Changes in blood osmotic pressure would most affect the secretion of?
ADH (Antidiuretic Hormone)
Does alcohol alter ADH and Aldosterone?
Alcohol (ethanol) acts on the hypothalamus to inhibit ADH secretion. This leads to diuresis and the typical repeated trips to the bathroom while at the bar drinking.
Neurohypophyseal secretion of stimulates formation of concentrated urine?
Neurohypophyseal secretion of antidiuretic hormone or ADH stimulates the formation of concentrated urine. This hormone is also known as argipressin.
What is ADH and how is its secretion controlled by negative feedback?
ADH is know as vassopressin and is produces by the hypothalamus and stored in the posterior pituitary. It is a peptide neurohormone of about 9 amino acids in length. ADH stands for anti diuretic hormone and prevents excess urine formation by reabsorbing water. When osmoteceptor cells in the hypothalamus senses an increase in osmolaritg in the ECF, SON and PVN cells are stimulated to secrete ADH. Also baroreceptors in the large arteries sense decreases in blood pressure and blood volume due to fluid loss. This also stimulus ADH secretion in order to conserve water. Interestingly, alcohol inhibits ADH secretion, therefore producing very dilute urine which stimulates thirst.
What is the effect of alcohol to antidiuretic hormone secretion?
Ethyl Alcohol prevents the secretion of Anti-diuretic hormone from the the posterior pituitary, resulting in water and sodium loss and subsequent diuresis.
