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Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting.
Causes, incidence, and risk factorsWhen you bleed, the body launches a series of reactions that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors. (Factor XII is a coagulation factor in this series of reactions.)
Each factor has a reaction that triggers the next reaction. The final product of the coagulation cascade is the blood clot.
A lack of factor XII does not cause the affected person to bleed abnormally, but the blood takes longer than normal to clot in a test tube.
Factor XII deficiency is a rare inherited disorder.
SymptomsThere are usually no symptoms.
Signs and testsFactor XII deficiency is usually found when clotting tests are done for routine screening.
Tests may include:
- Factor XII assay
- Partial thromboplastin time (PTT)
Treatment is generally unnecessary.
Expectations (prognosis)The outcome is expected to be good without treatment.
ComplicationsThere are usually no complications.
Calling your health care providerThis condition is usually discovered by the health care provider, when prolonged clotting is noticed in the process of running other laboratory tests.
PreventionThis is an inherited disorder. There is no known way to prevent it.
ReferencesKessler C. Hemorrhagic disorders: Coagulation factor deficiencies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 180.
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∙ 13y ago
Wiki User
∙ 12y agoFactor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting.
Causes, incidence, and risk factorsWhen you bleed, the body launches a series of reactions that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors. (Factor XII is a coagulation factor in this series of reactions.)
Each factor has a reaction that triggers the next reaction. The final product of the coagulation cascade is the blood clot. When one or more of these clotting factors are missing, there is usually a higher chance of bleeding.
A lack of factor XII does not cause the affected person to bleed abnormally, but the blood takes longer than normal to clot in a test tube.
Factor XII deficiency is a rare inherited disorder.
SymptomsThere are usually no symptoms.
Signs and testsFactor XII deficiency is usually found when clotting tests are done for routine screening.
Tests may include:
- Factor XII assay
- Partial thromboplastin time (PTT)
Treatment is usually not needed.
Expectations (prognosis)The outcome is expected to be good without treatment.
ComplicationsThere are usually no complications.
Calling your health care providerThe health care provider usually discovers this condition after noticing prolonged clotting in the process of running other laboratory tests.
PreventionThis is an inherited disorder. There is no known way to prevent it.
ReferencesGailani D, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier;2008:chap 127.
Kessler C. Hemorrhagic disorders: Coagulation factor deficiencies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 180.
Reviewed ByReview Date: 02/28/2011
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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What is the cpt code for clotting factor XII (Hageman factor) for excessive bleeding menopausal onset?
627.0
What are the 12 factors of blood clot?
http://web.indstate.edu/thcme/mwking/blood-coagulation.html Factor I = Fibrinogen Factor II = Prothrombin Factor III = Tissue factor Factor IV = Calcium Factor V = Labile factor Factor VI - Does not exist as it was named initially but later on discovered not to play a part in blood coagulation. Factor VII = Stable factor Factor VIII = Antihemophilic factor A Factor IX = Antihemophilic factor B or Christmas factor (named after the first patient in whom the factor deficiency was documented) Factor X = Stuart Prower factor Factor XI = Antihemophilic factor C Factor XII = Hageman factor Factor XIII = Fibrin stabilising factor
What is prekallikrein?
Prekallikrein (PK), also known as Fletcher factor, is a 85,000 Mr serine protease that complexes withHigh-molecular-weight Kininogen. PK is the precursor of plasma kallikrein, which is a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII (Hageman factor).
What initiates coagulation?
When the blood vessel is injured, so is the endothelium, so it releases the endothelium tissue factor (TF), which complexes with factor VII, activating it, which then activates factor X and IX and the rest of the cascade continues.Collagen is also exposed to a molecular, called high molecular weight kininogen (HMWK), prekallikrein and Hageman factor (factor XII), forming a complex. Prekallikrein is converted to Kallikrein and factor XII is activated to produced factor XIIa, which then activates factor XI and then factor X (the common factor between those two pathways), and the rest of the cascade continues, till the formation of the blood clot.
What are the 13 clotting factors?
factor I (fibrinogen), factor II (prothrombin), factor III (tissue thromboplastin), factor IV (calcium), factor V (proaccelerin), factor VI (no longer considered active in hemostasis), factor VII (factor-vii), factor VIII (antihemophilicfactor), factor IX (plasma thromboplastincomponent; Christmas factor), factor X (stuart-factor-stuart-prower-factor), factor XI (plasma thromboplastinantecedent), factor XII (factor-xii), factor XIII (fibrin stabilizing factor).
What is the highest common factor of cxx and cclii in roman numerals?
If the highest common factor of 120 and 252 is 12 10*12 = 120 21*12 = 252 Then it follows that the highest common factor of CXX and CCLII is XII X*XII = CXX XXI*XII = CCLII
In what general way do the intrinsic and extrinsic mechanisms of clotting differ?
extrinsic pathway of coagulation the mechanism that produces fibrin following tissue injury, beginning with formation of an activated complex between tissue factor and factor VII and leading to activation of factor X, inducing the reactions of the common pathway of coagulation.intrinsic pathway of coagulation a sequence of reactions leading to fibrin formation, beginning with the contact activation of factor XII, and resulting in the activation of factor X to initiate the common pathway of coagulation.
Factor XII assay?
DefinitionThe factor XII assay is a blood test to measure the activity of factor XII -- one of the substances involved in blood clotting.Alternative NamesHageman factor assayHow the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The area is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.How to prepare for the testThere is no special preparation needed for adults.How the test will feelWhen the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.Why the test is performedYour doctor may order this test if you had abnormal results on the partial thromboplastin time (PTT) blood-clotting test.Normal ValuesA normal value is 50 - 200% of the laboratory control or reference value.Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.What abnormal results meanDecreased factor XII activity may indicate:Inherited (congenital) deficiency of factor XIILiver diseaseWhat the risks areVeins and arteries vary in size from one patient to another, and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.Other risks associated with having blood drawn are slight but may include:Excessive bleedingFainting or feeling light-headedHematoma (blood accumulating under the skin)Infection (a slight risk any time the skin is broken)Special considerationsPeople with factor XII deficiency usually do not have excess bleeding. Factor XII does not appear to be needed for clots to form during the normal process of stopping bleeding.ReferencesKessler C. Hemorrhagic disorders: Coagulation factor deficiencies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 180.
What is thromboplastin?
substance in blood and tissues which, in the presence of ionized calcium, aids in the conversion of prothrombin to thrombin. Extrinsic and intrinsic thromboplastin are formed as the result of the interaction of different clotting factors; the factors that combine to form extrinsic thromboplastin are not all derived from intravascular sources, whereas those that form intrinsic thromboplastin are.activated partial t. time - see http://www.answers.com/topic/activated-4 partial thromboplastin time.extrinsic t. - the prothrombin activator formed as a result of interaction of coagulation factors III, VII, and X which, with factor IV, aids in the formation of thrombin.t. generation time (TGT) - evaluates the first stage in blood coagulation by measuring the efficiency of prothrombinase formation.intrinsic t. - the prothrombin activator formed as a result of interaction of coagulation factors V, VII, IX, X, XI and XII and platelet factor 3 (PF-3), which, with factor IV, aids in the conversion of prothrombin to thrombin.plasma t. antecedent (PTA) - http://www.answers.com/topic/clotting-1 factor XI; deficiency occurs in cattle and dogs, causing mild to severe bleeding tendencies called hemophilia C.plasma t. component (PTC) - http://www.answers.com/topic/clotting-1 factor IX; deficiency causes http://www.answers.com/topic/haemophilia-b. Called also Christmas factor, antihemophilic factor B, autoprothrombin II.t. time - see http://www.answers.com/topic/activated-4 partial thromboplastin time.tissue t. - factor III, a material derived from several sources in the body (e.g. brain, lung), and is important in the formation of extrinsic prothrombin converting principle in the extrinsic pathway of blood coagulation. Called also tissue factor.
What does the roman numberal xii mean?
xii or XII = 12
What does XII mean in roman numeral?
In Roman numerals xii or XII are both equivalent to 12
What is XII-MM-XII?
XII-MM-XII is a Roman numeral representation of the date December 12, 12.
