Familial hypertriglyceridemia is a common disorder passed down through families in which the level of triglycerides (a type of fat) in a person's blood are higher than normal.
The condition is not associated with a significant increase in cholesterol levels.
Causes, incidence, and risk factorsFamilial hypertriglyceridemia is caused by a genetic defect, which is passed on in an autosomal dominant fashion. This means that if you get a bad copy of the gene from just one of your parents, you will have the condition.
Some people with this condition also have high levels of very low density lipoprotein (VLDL). The reason for the rise in triglycerides and VLDL is not understood.
Familial hypertriglyceridemia does not usually become noticeable until puberty or early adulthood. Obesity, hyperglycemia (high blood glucose levels), and high levels of insulin are often also present and may cause even higher triglyceride levels.
Familial hypertriglyceridemia occurs in about 1 in 500 individuals in the United States. Risk factors are a family history of hypertriglyceridemia or a family history of heart disease before the age of 50.
SymptomsYou may not notice any symptoms. People with the condition may have coronary artery disease at an early age.
Signs and testsPeople with a family history of this condition should have blood tests to check very low density lipoprotein (VLDL) and triglyceride levels. Blood tests usually show a mild to moderate increase in triglycerides (about 200 to 500 mg/dL).
A coronary risk profile may also be done.
TreatmentThe goal of treatment is to control conditions that can raise triglyceride levels such as obesity, hypothyroidism, and diabetes.
Your doctor may tell you not to drink alcohol. Because certain Birth Control pills can raise triglyceride levels, you should carefully discuss their use with your doctor.
Treatment also involves avoiding excess calories and foods high in saturated fats and carbohydrates. See also: Heart disease and diet
If high triglyceride levels persist despite diet changes, medication may be needed. Nicotinic acid, gemfibrozil, and fenofibrate have been shown to lower triglyceride levels in people with this condition.
Expectations (prognosis)Persons with this condition have an increased risk of coronary artery disease and pancreatitis.
Losing weight and keeping Diabetes under control helps improve the outcome.
ComplicationsScreening family members for high triglycerides may detect the disease early.
ReferencesMahley RW, Weisgraber KH, Bersot TP. Disorders of lipid metabolism. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 36.
Semenkovich CF. Disorders of lipid metabolism. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 217.
Familial hypertriglyceridemia is a common disorder passed down through families in which the level of triglycerides (a type of fat) in a person's blood are higher than normal.
The condition is not associated with a significant increase in cholesterol levels.
Causes, incidence, and risk factorsFamilial hypertriglyceridemia is caused by a genetic defect, which is passed on in an autosomal dominant fashion. This means that if you get a bad copy of the gene from just one of your parents, you will have the condition.
Some people with this condition also have high levels of very low density lipoprotein (VLDL). The reason for the rise in triglycerides and VLDL is not understood.
Familial hypertriglyceridemia does not usually become noticeable until puberty or early adulthood. Obesity, hyperglycemia (high blood glucose levels), and high levels of insulin are often also present and may cause even higher triglyceride levels.
Familial hypertriglyceridemia occurs in about 1 in 500 individuals in the United States. Risk factors are a family history of hypertriglyceridemia or a family history of heart disease before the age of 50.
SymptomsYou may not notice any symptoms. People with the condition may have coronary artery disease at an early age.
Signs and testsPeople with a family history of this condition should have blood tests to check very low density lipoprotein (VLDL) and triglyceride levels. Blood tests usually show a mild to moderate increase in triglycerides (about 200 to 500 mg/dL).
A coronary risk profile may also be done.
TreatmentThe goal of treatment is to control conditions that can raise triglyceride levels such as obesity, hypothyroidism, and diabetes.
Your doctor may tell you not to drink alcohol. Because certain birth control pills can raise triglyceride levels, you should carefully discuss their use with your doctor.
Treatment also involves avoiding excess calories and foods high in saturated fats and carbohydrates. See also: Heart disease and diet
If high triglyceride levels persist despite diet changes, medication may be needed. Nicotinic acid, gemfibrozil, and fenofibrate have been shown to lower triglyceride levels in people with this condition.
Expectations (prognosis)Persons with this condition have an increased risk of coronary artery disease and pancreatitis.
Losing weight and keeping diabetes under control helps improve the outcome.
ComplicationsScreening family members for high triglycerides may detect the disease early.
ReferencesMahley RW, Weisgraber KH, Bersot TP. Disorders of lipid metabolism. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 36.
Semenkovich CF. Disorders of lipid metabolism. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 217.
Reviewed ByReview Date: 05/23/2010
David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc., and David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine.
Familial - album - was created in 2001.
Familial in medical terms means hereditary.
We invited my grandparents over for a familial Christmas dinner.
yes because nevoid bAsal cell carcinoma is also familial
Familial polyposis or familial adenomatous polyposis (FAP) is a premalignant disease. This means that a person with FAP, if left untreated, will invariably develop cancer. Individuals with this disorder grow hundreds of polyps.
Familial means hereditary, running in families, hence predictable at times. Sporadic means randomly caused, with no heredity that an be traced, usually by a mutation in the same gene that causes the familial form of the disorder.
Four
Chromosome 9p has been identified as being involved in familial predisposition.
Chromosome 9p has been identified as being involved in familial predisposition.
Hello, I see you are asking "Is Familial polyposis cancerous" Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon ) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps ) in the colon as early as their teenage years. To get more info visit the url: orthopedicshealth. com/symptoms/directory/a
homosexual
There are mutations in up to 50% of familial melanoma patients of the tumor-suppressing gene CDKN2A.