Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is a hereditary condition in which red blood cells break down when the body is exposed to certain drugs or the stress of infection.
Alternative NamesG-6-PD deficiency; Hemolytic anemia due to G6PD deficiency; Anemia - hemolytic due to G6PD deficiency
Causes, incidence, and risk factorsG6PD deficiency occurs when a person is missing or doesn't have enough of an enzyme called glucose-6-phosphate dehydrogenase, which helps red blood cells work properly.
Too little G6PD leads to the destruction of red blood cells. This process is called hemolysis. When this process is actively occurring, it is called a hemolytic episode. The episodes are usually brief, because the body continues to produce new red blood cells, which have normal activity.
Red blood cell destruction can be triggered by infections, severe stress, certain foods (such as fava beans), and certain drugs, including:
Other chemicals, such as those in mothballs, can also trigger an episode.
In the United States, G6PD deficiency is more common among blacks than whites. Men are more likely to have this disorder than women.
You are more likely to develop this condition if you:
A form of this disorder is common in whites of Mediterranean descent. This form is also associated with acute episodes of hemolysis. Episodes are longer and more severe than in the other types of the disorder.
SymptomsPersons with this condition do not display any signs of the disease until their red blood cells are exposed to certain chemicals in food or medicine, or to stress.
Symptoms are more common in men and may include:
A blood test can be done to check the level of G6PD. See: G6PD screen
Other tests that may be done include:
Treatment may involve:
Spontaneous recovery from a hemolytic episode is the usual outcome.
ComplicationsRarely, kidney failure or death may occur following a severe hemolytic event.
Calling your health care providerCall for an appointment with your health care provider if you have symptoms of this condition.
Call your health care provider if you have been diagnosed with G6PD deficiency and symptoms do not disappear after treatment.
PreventionPersons with G6PD deficiency must strictly avoid things that can trigger an episode. Talk to your health care provider about your medications.
Genetic counseling or testing may be available to those who have a family history of the condition.
ReferencesGregg XT, Prchal JT. Red blood cell enzymopathies. In: Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingston; 2008:chap 45.
Golan DER. Hemolytic anemias: red cell membrane and metabolic defects. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 165.
G6PD deficiency is caused by one copy of a defective G6PD gene in males or two copies of a defective G6PD gene in females. Hemolytic anemic attacks can be caused by oxidants, infection, and or by eating fava beans.
No. They won't accept your blood
Glucose 6 phosphate dehydrogenase is an enzyme necessary for the metabolism of red blood cells. Its deficiency leads to hemolytic anemia usually triggered by exposure to some drugs.
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Blood disease Liver disease Nerve or brain disease or disorder, including seizures (convulsions) Past or current mental disorder Stomach or intestinal disease Deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD
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