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Hypervitaminosis A

Updated: 12/17/2022
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13y ago

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Definition

Hypervitaminosis A is having too much vitamin A in the body.

Alternative Names

Vitamin A toxicity

Causes, incidence, and risk factors

There are two types of vitamin A hypervitaminosis:

  • Acute -- caused by taking too much vitamin A over a short period of time
  • Chronic -- occurs when too much of the vitamin is present over a longer period

Chronic vitamin A toxicity develops after taking too much vitamin A for long periods.

Symptoms
  • Abnormal softening of the skull bone (craniotabes -- infants and children)
  • Blurred vision
  • Bone pain or swelling
  • Bulging fontanelle (infants)
  • Changes in consciousness
  • Decreased appetite
  • Dizziness
  • Double vision (young children)
  • Drowsiness
  • Headache
  • Increased intracranial pressure
  • Irritability
  • Liver damage
  • Nausea
  • Poor weight gain (infants and children)
  • Skin and hair changes
    • Cracking at corners of the mouth
    • Hair loss
    • Higher sensitivity to sunlight
    • Oily skin and hair (seborrhea)
    • Skin peeling, itching
    • Yellow discoloration of the skin
  • Vision changes
  • Vomiting
Signs and tests
  • Bone x-rays
  • Blood calcium test
  • Cholesterol test
  • Liver function test
  • Blood test to check vitamin A levels
Treatment

Treatment involves simply stopping the use of too much vitamin A.

Expectations (prognosis)

Most people fully recover.

Complications
  • Excessively high calcium levels
  • Failure to thrive in infants
  • Kidney damage due to high calcium
  • Liver damage

Taking too much vitamin A during pregnancy may cause abnormal development in the developing baby. Talk to your health care provider about eating a proper diet while you are pregnant.

Calling your health care provider

Call your health care provider if you think that you or your child may have taken too much vitamin A, or you have symptoms of excess vitamin A.

Prevention

To avoid hypervitaminosis A, avoid taking more than the recommended daily allowance of this vitamin. Recent emphasis on vitamin A and beta carotene as anticancer vitamins may contribute to chronic hypervitaminosis A, if people take more than is recommended.

References

Zile M. Vitamin A deficiencies and excess. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 45.

Mason JB. Vitamins, trace minerals, and other micronutrients. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 237.

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13y ago
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Wiki User

12y ago
Definition

Hypervitaminosis A is having too much vitamin A in the body.

Alternative Names

Vitamin A toxicity

Causes, incidence, and risk factors

There are two types of vitamin A hypervitaminosis:

  • Acute -- caused by taking too much vitamin A over a short period of time
  • Chronic -- occurs when too much of the vitamin is present over a longer period

Chronic vitamin A toxicity develops after taking too much vitamin A for long periods.

Symptoms
  • Abnormal softening of the skull bone (craniotabes -- infants and children)
  • Blurred vision
  • Bone pain or swelling
  • Bulging fontanelle (infants)
  • Changes in consciousness
  • Decreased appetite
  • Dizziness
  • Double vision (young children)
  • Drowsiness
  • Headache
  • Increased intracranial pressure
  • Irritability
  • Liver damage
  • Nausea
  • Poor weight gain (infants and children)
  • Skin and hair changes
    • Cracking at corners of the mouth
    • Hair loss
    • Higher sensitivity to sunlight
    • Oily skin and hair (seborrhea)
    • Skin peeling, itching
    • Yellow discoloration of the skin
  • Vision changes
  • Vomiting
Signs and tests
  • Bone x-rays
  • Blood calcium test
  • Cholesterol test
  • Liver function test
  • Blood test to check vitamin A levels
Treatment

Treatment involves simply stopping the use of too much vitamin A.

Expectations (prognosis)

Most people fully recover.

Complications
  • Excessively high calcium levels
  • Failure to thrive in infants
  • Kidney damage due to high calcium
  • Liver damage

Taking too much vitamin A during pregnancy may cause abnormal development in the developing baby. Talk to your health care provider about eating a proper diet while you are pregnant.

Calling your health care provider

Call your health care provider if you think that you or your child may have taken too much vitamin A, or you have symptoms of excess vitamin A.

Prevention

To avoid hypervitaminosis A, avoid taking more than the recommended daily allowance of this vitamin. Recent emphasis on vitamin A and beta carotene as anticancer vitamins may contribute to chronic hypervitaminosis A, if people take more than is recommended.

References

Zile M. Vitamin A deficiencies and excess. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 45.

Mason JB. Vitamins, trace minerals, and other micronutrients. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 237.

Reviewed By

Review Date: 05/23/2010

David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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Related questions

What is one possible consequence of hypervitaminosis of vitamin A?

One possible consequence of Hypervitaminosis A is reduced bone density that can lead to osteoporosis.


What else is vitamin toxicity called?

called hypervitaminosis or vitamin poisoning


What would a cat take for milk fever?

* Intravenous fluids * Bisphosphonates (drugs that stop bone resorption such as pamidronate or etidronate) * Calcitonin * Glucocorticoids (steroids, for hypervitaminosis D that is not medication related) * Hemodialysis (for hypercalcemia that is unresponsive to treatment and is life-threatening)


In hypervitaminosis A D why does calcium deposit in kidney and not in liver and why does vit A store in liver and not in kidney?

The body stores excessive Vitamin A in the liver for later use if needed. Vitamin D however needs to be converted to a different form to be biologically active. This conversion after it leaves the liver, occurs in the kidney where it is converted to 1,25-dihydroxycholecalciferol, a biologically active form.


What vitamin excess use is dangerous to health?

Excess of vitamin intake or vitamin overdose is called hypervitaminosis. It is a condition of high storage levels of vitamin, which can lead to toxicity.Hypervitaminosis A is an excess of vitamin A, Similarly Hypervitaminosis C an excess of vitamin C, and so on.High or toxic levels of vitamins occur when you have high supplement intake and when you do not take from dietary sources.


Is taking 25 different vitamins everyday bad for you?

Most vitamins taken are okay to ingest in excess. Exceeding the daily requirement by more than 125% is not necessarily going to help you, however. Your body will just get rid of what it doesn't need (water-soluble vitamins). Consult your doctor or pharmacist regarding the 25 different vitamins that you are taking, as some may affect any medications you may be taking. Be sure that you are not taking too much of a particular vitamin that may not be removed in excess from the body (fat-soluble vitamins). View attached chart to learn more about hypervitaminosis (excess intake of particular vitamins) and what the recommended intake is.


What vitamin should you take when you smoke?

You should have an adequate supply of antioxidant vitamins, like Vitamin C and Vitamin E. You should also ensure that you eat colored vegetables, which contain flavonoids, in addition to Vitamin A (also an antioxidant). Intake of vitamin A preparations are not recommended, as excess of it may cause hypervitaminosis A.


Hypervitaminosis D?

DefinitionHypervitaminosis D is a condition that occurs after taking excessive doses of vitamin D.Alternative NamesVitamin D toxicityCauses, incidence, and risk factorsAn excess of vitamin D causes abnormally high levels of calcium in the blood, which can eventually severely damage the bones, soft tissues, and kidneys. It is almost always caused by forms of vitamin D that require a doctor's prescription.SymptomsConstipationDecreased appetite (anorexia)DehydrationFatigueIrritabilityMuscle weaknessVomitingSigns and testsExcess calcium in the blood (hypercalcemia)Excess calcium in the urine (hypercalciuria)Excessive thirst (polydipsia)High blood pressurePassing large amounts of urine (polyuria)Tests to confirm the diagnosis:1,25 dihydroxyvitamin D levels25-hydroxyvitamin D levelsSerum calciumSerum phosphorusX-ray of the boneTreatmentStop taking vitamin D. Consult your physician. In severe cases, other treatment may be necessary.Expectations (prognosis)Recovery is expected.ComplicationsDehydrationHypercalcemiaKidney damageKidney stonesCalling your health care providerCall your health care provider if:You or your child shows symptoms of hypervitaminosis D and has been taking more vitamin D than the recommended daily allowanceYou or your child shows symptoms and has been taking a prescription form of vitamin DPreventionTo prevent this condition, pay careful attention to the correct vitamin D dose.


What diseases can be caused by lack of calcium in your diet?

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What is the Medical term meaning excess vitamin c?

My 2 year old nephew drank 88+ounces of sunny delight in a 2 hour period.What kind of side effects can ocurBack pain, jaundice (yellow skin and eyes), itchy skin, tender mass in left upper abdomen, and fever.Too much Vitamin C is virtually harmless. Vitamin C (Ascorbic Acid) is a water-soluble vitamin. This means that if the body gets too much of it, it will just excrete out what it doesn't need. I remember my Biochemistry professor calling this "expensive urine." Too much Vitamin C can cause some of the above symptoms but it would be unlikely. The most common symptom of too much Vitamin C is diarrhea and increased urine concentration.A serving size of 8 oz of Sunny Delight is about 100% daily value (about 60 mg) of Vitamin C. This means that 88 oz would be about 1100% of daily value of Vitamin C (about 660 mg).The United States defined Tolerable Upper Intake Level for a 25-year-old male is 2,000 milligrams per day. 660 mg vs. 2000 mg means it won't even affect the child that much. If you are unsure, consult your physician. Just to let you know, when I was a kid I used to eat Vitamin C tablets (about 1500 mg). Sometimes I would have 2 or 3 and it never hurt me a bit.The actual medical term for excess vitamin C in the body is "Hypervitaminosis C". Literally, it means "the condition of high vitamin C".


What causes hyperphosphatemia in dogs?

Hyperphosphatemia ---- * Spurious Hyperphosphatemia1) Hemolysis: Hemolysis or prolonged contact of serum with cells in the blood sample causes movement of phosphate from the red cells into serum and can raise the Pi result.2) Post-prandial: A mild increase occurs after eating.3) Monoclonal gammopathy: Hyperphosphatemia can be observed in monoclonal gammopathies, due to binding of phosphate to the monoclonal protein.* Decreased excretion1) Decreased GFR: This is the most common cause of hyperphosphatemia. Many animals that are azotemic are also hyperphosphatemic. Acute and severe reduction in GFR, as in acute renal failure or severe hypovolemia, is more likely to result in hyperphosphatemia than is chronic renal failure.2) Hypoparathyroidism: Phosphate is retained whilst calcium is lost in the urine due to lack of PTH.3) Acromegaly: Growth hormone promotes retention of phosphate.4) Hyperthyroidism: Phosphate is increased in up to 21% of hyperthyroid cats.* Increased absorption1) Hypervitaminosis D: This produces hyperphosphatemia as well as hypercalcemia.2) Increased intake: Ingestion of excess phosphate (nutritional hyperparathyroidism) or administration of phosphate containing fluids or compounds. Use of hypertonic phosphate enemas (Fleet) in cats has been recognized to cause extreme hyperphosphatemia through absorption of phosphate. Hypernatremia, hypokalemia, hypocalcemia, and high anion gap metabolic acidosis are additional abnormalities. Affected cats can die. Morbidity and mortality resulting from use of Fleet enemas is increased by prolonged retention of the hypertonic phosphate, mucosal defects enhancing absorption, and pre-existing abnormalities in water and electrolyte balance. This product should be administered to cats with extreme caution if used at all.* Transcellular shifts1) Acute tumor lysis syndrome: This results in high phosphate, high potassium, high uric acid and low calcium. Animals often die of acute oliguric renal failure.2) Severe soft tissue trauma: This can also result in increased phosphate as phosphate is higher intracellularly than extracellularly, e.g. rhabdomyolysis.


What happens when you get too much vitamin a?

A toxicity, an excessive amount that is poisonous in the body. Too many supplements can create an excessive amounts of Vitamin A that cause headaches, vomiting, double vision, abnormal bones, and liver damage. Added by makkarjs As vitamin A is fat-soluble, disposing of any excesses taken in through diet is much harder than with water-soluble vitamins B and C. As such, vitamin A toxicity can result. This can lead to nausea, jaundice, irritability, anorexia (not to be confused with anorexia nervosa, the eating disorder), vomiting, blurry vision, headaches, muscle and abdominal pain and weakness, drowsiness and altered mental status. source : http://en.wikipedia.org/wiki/Vitamin_a#Toxicity