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Leiomyosarcoma

Updated: 9/27/2023
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13y ago

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Definition

A leiomyosarcoma is a rare cancerous tumor of the smooth muscle cells. It is most often found in the uterus or abdomen.

References

Lahat G, Lazar A, Lev D. Sarcoma epidemiology and etiology: Potential environmental and genetic factors. Surg Clin North Am. 2008;88:451-481.

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13y ago
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Wiki User

12y ago
Definition

A leiomyosarcoma is a rare cancerous tumor of the smooth muscle cells. It is most often found in the uterus or abdomen.

References

Lahat G, Lazar A, Lev D. Sarcoma epidemiology and etiology: Potential environmental and genetic factors. Surg Clin North Am. 2008;88:451-481.

Reviewed By

Review Date: 01/31/2010

Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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Related questions

How do you pronounce leiomyosarcoma?

leiomyosarcoma


Is leiomyosarcoma hereditary?

no


What is leiomyosarcoma?

Leiomyosarcoma means "white muscle tumor" - it is a malignant cancer that started out in smooth muscle, such as the muscles of the uterus or the gastrointestinal tract. It is a relatively rare cancer, although occasionally older cows may be seen with it.


When did Irwin Barker die?

Irwin Barker died on June 21, 2010, in Toronto, Ontario, Canada of leiomyosarcoma.


When did Diana Sands die?

Diana Sands died on September 21, 1973, in New York City, New York, USA of leiomyosarcoma.


What is the medical term meaning malignant tumor that arises from connective tissues including hard tissues soft tissues and liquid tissues?

The perioisteum is the connective tissue covering the bone.


What is cancer of the womb?

The term "womb" generally refers to the uterus during pregnancy. So cancers of the womb would include all cancers that affect the uterus. There are several types, all of which have specific names (eg, leiomyosarcoma).Another type of cancer that might be associated with the term "womb" is a choriocarcinoma. Choriocarcinoma is a cancer of the placenta. It is relatively common in so-called "molar" pregnancies, specifically complete hydatidiform moles.


How long do dogs live with leiomyosarcoma?

Long-term follow-up information was obtained for 39 dogs that had undergone surgical excision of nonlymphomatous, small intestinal tumors. For all dogs evaluated in this study, the median survival time was 10 months, and the one- and two-year survival rates were 40.5% and 33.1%, respectively. There was no difference in survival times between dogs with adenocarcinomas (n=23) and dogs with leiomyosarcomas (n=16). Survival times were significantly (p less than 0.0001) shorter for dogs with histological evidence of metastases at the time of surgery (median, 3.0 months) than for dogs with no histiological evidence of metastases (median, 15.0 months).


What is the medical term meaning benign smooth muscle tumor?

Smooth muscle (unlike skeletal muscle) consists of individual cells (leiomyocytes), each cell with its own nucleus.The function of smooth muscle also differs substantially from that of striated muscle.Each smooth muscle cell (or "muscle fiber") is just a few microns in diameter but may be two hundred microns long. The nucleus is also elongated, often cigar-shaped. The appearance, or visual texture, of smooth muscle varies dramatically depending on the orientation of the fibers with respect to the plane of section. Note especially the appearance of smooth muscle nuclei.an involintary muscle found in you're skin blood vessles and organs


What is the medical term meaning Malignant tumor of connective or supportive tissue?

Sarcoma (for examp. Langerhern Cell Sarcoma, Sarcoma of Ewing). addition! Reticulosarcoma (means sarcoma of the reticulocyte cells) A malignant tumor of connective tissue is called Sarcoma. There are three different subcategories: Hard Tissue Sarcomas (can occur in bone or cartilage), Soft Tissue Sarcomas (can occur in muscles, tendons, or lymphatic vessels) , and Liquid Tissue Sarcomas (can occur in blood and lymph)


Where can someone purchase a cancer ribbon?

During breast cancer awareness month one can find them at the check outs of many major stores such as Wal-mart. They can also be made at custom jewelry stores. Or they can be purchased on Amazon or eBay.


Uterine fibroids?

DefinitionUterine fibroids are noncancerous (benign) tumors that develop in the uterus (womb), a female reproductive organ.Alternative NamesLeiomyoma; Fibromyoma; Myoma; FibroidsCauses, incidence, and risk factorsUterine fibroids are the most common pelvic tumor. As many as 1 in 5 women may have fibroids during their childbearing years (the time after starting menstruation for the first time and before menopause).Fibroids usually affect women over age 30. They are rare in women under 20, and often shrink and cause no symptoms in women who have gone through menopause. They are more common in African Americans than Caucasians.The cause of uterine fibroid tumors is unknown. However, fibroid growth seems to depend on the hormone estrogen. As long as a woman with fibroids is menstruating, a fibroid will probably continue to grow, usually slowly.Fibroids can be so tiny that you need a microscope to see them. However, they can grow very large. They may fill the entire uterus, and may weigh several pounds. Although it is possible for just one fibroid to develop, usually there are more than one.Fibroids are often described by their location in the uterus:Myometrial -- in the muscle wall of the uterusSubmucosal -- just under the surface of the uterine liningSubserosal -- just under the outside covering of the uterusPendunculated -- occurring on a long stalk on the outside of the uterus or inside the cavity of the uterusSymptomsMore common symptoms of uterine fibroids are:Abdominal fullness, gas, or constipationBleeding between periodsIncrease in urinary frequencyHeavy menstrual bleeding (menorrhagia), sometimes with the passage of blood clotsMenstrual periods that may last longer than normalPelvic cramping or pain with periodsSensation of fullness or pressure in lower abdomenPain during intercourseNote: There are often no symptoms.Signs and testsA pelvic examination may show an irregularly shaped, lumpy, or enlarged uterus. Frequently, this diagnosis is reliable. In some cases, it is difficult to diagnose fibroids, especially in obese women. Fibroid tumors have been mistaken for:PregnancyOvarian tumorsInflammation of the fallopian tubesUterine adenomyosis (a condition in which the uterine lining grows into the muscle wall of the uterus)A transvaginal ultrasound or pelvic ultrasound may be done to confirm the diagnosis of fibroids. Sometimes, a pelvic MRI is used to confirm the diagnosis.An endometrial biopsy (biopsy of the uterine lining) or laparoscopy may be needed to rule out cancer.TreatmentTreatment depends on various factors, including:AgeGeneral healthSeverity of symptomsType of fibroidsWhether you are pregnantIf you want children in the futureSome women may just need pelvic exams or ultrasounds every once in a while to monitor the fibroid's growth.Treatment for the symptoms of fibroids may include:Birth control pills (oral contraceptives) to help control heavy periodsIntrauterine devices (IUDs) that release the hormone progestin to help reduce heavy bleeding and painIron supplements to prevent or treat anemia due to heavy periodsNonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naprosyn for cramps or painHormonal therapy (gonadotropin releasing hormone (GnRH) agonists or Depo Leuprolide injections) may be used to help shrink the fibroids. This therapy is used only for a short period of time, either before surgery to remove a fibroid or when a woman is expected to reach menopause soon. Side effects include hot flashes and vaginal dryness.Surgery and procedures used to treat fibroids include:Hysteroscopic resection of fibroids: Women who have fibroids growing inside the uterine cavity may need this outpatient procedure. In this procedure, a small camera and instruments are inserted through the cervix into the uterus to remove the fibroid tumors.Uterine artery embolization: This procedure stops the blood supply to the fibroid, causing it to die and shrink. Uterine artery embolization is not used to treat large fibroids. Women who may want to become pregnant in the future should NOT have this procedure.Myomectomy: This surgery removes the fibroids. It is often the chosen treatment for women who want to have children, because it usually can preserve fertility. Another advantage of a myomectomy is that it controls pain or excessive bleeding that occurs in some women with uterine fibroids. More fibroids can develop after a myomectomy.Hysterectomy: This invasive surgery may be an option if medicines do not work and other surgeries and procedures are not an option.Support GroupsNational Uterine Fibroid Foundation - www.nuff.orgExpectations (prognosis)Some women with fibroids have no symptoms and may not need treatment.During a pregnancy, existing fibroids may grow due to the increased blood flow and estrogen levels. The fibroids usually return to their original size after the baby is delivered.ComplicationsFibroids may cause pregnancy complications, although the risk is thought to be small:Most women are able to carry their babies to term, but some end up delivering prematurely because there is not enough room in the uterus.Some pregnant women with fibroids may need a cesarean section because fibroids can occasionally block the birth canal or cause the baby to be positioned wrong.Some pregnant women with fibroids have heavy bleeding immediately after giving birth.Other complications of fibroids include:Severe pain or excessively heavy bleeding that may require emergency surgeryA pedunculated fibroid can become twisted and cause a kink in the blood vessels feeding the tumor (this type of fibroid may need surgery)Anemia (which may be severe if the bleeding is very heavy)Urinary tract infections, if pressure from the fibroid prevents the bladder from fully emptyingCancerous changes called leiomyosarcoma (in rare cases)Infertility (rarely)Calling your health care providerCall your health care provider if:You have gradual changes in your menstrual pattern, including a heavier flow, increased cramping, or bleeding between periodsFullness or heaviness develops in your lower abdomenReferencesKatz VL. Benign gynecologic lesions: Vulva, vagina, cervix, uterus, oviduct, ovary. In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, eds. Comprehensive Gynecology. 5th ed. Philadelphia, Pa: Mosby Elsevier; 2007:chap 18.Viswanathan M, Hartmann K, et al. Management of uterine fibroids: an update of the evidence. Evid Rep Technol Assess. 2007;154:1-122.Van Voorhis B. A 41-year-old woman with menorrhagia, anemia, and fibroids: review of treatment of uterine fibroids. JAMA. 2009;301:82-93.American College of Obstetricians and Gynecologists. ACOG practice bulletin. Alternatives to hysterectomy in the management of leiomyomas. Obstet Gynecol. 2008;112:387-400.