Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope.
Alternative NamesMinimal change nephrotic syndrome; Nil disease; Lipoid nephrosis; Idiopathic nephrotic syndrome of childhood
Causes, incidence, and risk factorsEach kidney is made of more than a million units called nephrons, which filter blood and produce urine.
In minimal change disease, there is damage to the glomeruli -- the tiny blood vessels inside the nephron. The disease gets its name because this damage isn't visible under a regular microscope. It can only be seen under an electron microscope.
Minimal change disease is the most common cause of nephrotic syndrome in children. It is also seen in adults.
The cause is unknown, but the disease may occur after:
There may be symptoms of nephrotic syndrome:
Minimal change disease does not reduce the amount of urine produced. It rarely progresses to kidney failure.
Signs and testsThe doctor may not be able to see any obvious outward signs of the disease, other than swelling. Blood and urine tests reveal signs typical of nephrotic syndrome, including:
A kidney biopsyand examination of the tissue with an electron microscope can show signs of minimal change disease. An immunofluorescence exam of the biopsied kidney tissue is negative.
TreatmentCorticosteroids can cure minimal change disease in most children. Some patients may need to stay on steroids to keep the disease in remission.
Adults do not respond to steroids quite as well as children, but many still do find steroids effective. Adults may have more frequent relapses and steroid dependence.
Patients who have three or more relapses may do better with cytotoxic therapy. In most cases, this involves a medication called cyclophosphamide. Other medicines that have been used include cyclosporine and chlorambucil.
Swelling may be treated with:
You may also be told to reduce the amount of salt in your diet.
Expectations (prognosis)Minimal change disease usually responds well to corticosteroids, often within the first month. A relapse can occur, but patients may improve after prolonged treatment with corticosteroids and medications that suppress the immune system (immunosuppressive medications).
ComplicationsCall for an appointment with your health care provider if you develop symptoms of minimal change disease.
If you have this disorder, call for an appointment with your health care provider if your symptoms worsen or you develop new symptoms, including side effects from the medications used to treat the disorder.
PreventionThere is no known prevention.
ReferencesAppel GB. Glomerular disorders and nephrotic syndromes. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 122.
Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope.
Alternative NamesMinimal change nephrotic syndrome; Nil disease; Lipoid nephrosis; Idiopathic nephrotic syndrome of childhood
Causes, incidence, and risk factorsEach kidney is made of more than a million units called nephrons, which filter blood and produce urine.
In minimal change disease, there is damage to the glomeruli -- the tiny blood vessels inside the nephron where blood is filtered to make urine and waste is removed. The disease gets its name because this damage is not visible under a regular microscope. It can only be seen under an electron microscope.
Minimal change disease is the most common cause of nephrotic syndrome in children. It causes about 80% of cases in young children. It is also seen in adults, but makes up only 10 to 15% of nephrotic syndrome cases.
The cause is unknown, but the disease may occur after or be related to:
There may be symptoms of nephrotic syndrome:
Minimal change disease does not reduce the amount of urine produced. It rarely progresses to kidney failure.
Signs and testsThe doctor may not be able to see any signs of the disease, other than swelling. Blood and urine tests reveal signs of nephrotic syndrome, including:
A kidney biopsyand examination of the tissue with an electron microscope can show signs of minimal change disease. An immunofluorescence exam of the biopsied kidney tissue will be negative.
TreatmentCorticosteroids can cure minimal change disease in most children. Some patients may need to stay on steroids to keep the disease in remission.
Adults do not respond to steroids as well as children, but many still find steroids effective. Adults may have more frequent relapses and become dependent on steroids.
Patients who have three or more relapses may do better with cytotoxic therapy instead of steroids. In most cases, this involves a medication called cyclophosphamide. Other medicines that have been used include cyclosporine and chlorambucil.
Swelling may be treated with:
You may also be told to reduce the amount of salt in your diet.
Expectations (prognosis)Children with minimal change disease usually respond better to corticosteroids than adults. Children often respond within the first month.
A relapse can occur. However, patients may improve after long-term treatment with corticosteroids and medications that suppress the immune system (immunosuppressive medications).
ComplicationsCall for an appointment with your health care provider if:
There is no known prevention.
ReferencesAppel GB. Glomerular disorders and nephrotic syndromes. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 122.
Nachman PH, Jennette JC, Falk RJ. Primary glomerular disease. In: Brenner BM, ed. Brenner and Rector's the Kidney. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 30.
Pais P, Avner ED. Nephrotic syndrome. In: Kliegman RM, Stanton BF, St. Geme JW III, Schor NF, Behrman RE, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 521.
Reviewed ByReview Date: 09/20/2011
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Herbert Y. Lin, MD, PHD, Nephrologist, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Prognosis depends on the underlying disorder. Minimal change disease has the best prognosis of all the kidney disorders, with 90% of all patients responding to treatment. Other types of kidney diseases have less favorable outcomes.
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