year and engine size would help, but here are some fixes always check cyl compression. next make sure injector is getting a pulse signal from pcm quick way use a long screwdriver as a stethoscope place one end on injector and handle end on your ear if you hear a mechanical clicking on that injector you have a signal. back to spark just because you have spark with pulling wire off when car is running does not mean you have good spark when spark plug is trying to fire under compression. most times its a coil pack breaking down under load.if the misfire goes away once you get the rpms going and its more of a idle misfire then you want to check for a vacuum leak around cyl 5 or a sticky egr valve will cause vacuum leak like problems. my bet is the coil or wire. if you need help describe your car and what type of drivability issues you have will be glad to get you through it
The #1 cylinder is located closest to the front of engine, which is where the pulley that drives serpentine belt is. Ensure injector is getting pulse before replacing.
plugged up fuel injector or bad injector itself.
Coil, injector, internal engine....
Replacing the injector itself is not a difficult task. Getting to it is yet another question. You will probably save time and money by taking it to a shop if you do not have the proper tools or experience for removing and replacing fuel rails.
You could be getting a little cylinder "wash down" from an injector that's sticking open. Try a little fuel injector cleaner in the next tank of fuel.
Check the timing on your vehicle ,but there's more on why your getting a misfire
I'm not a mechanic / technician but I BELIEVE if the fuel injector is restricted so that the proper air - fuel mixture is not getting to an engine cylinder , that an engine cylinder misfire can occur ( that is only one of the causes of an engine cylinder misfire )
I would make sure power is getting to the fuel injector use a noid light to test it. You may also want to check the fuel pressure also the intake manifold may have a leak that can cause a misfire as well. Glad your compression is good. That is a sure sign its something simple.
Could be a faulty spark plug or fuel injector for that cylinder. Try getting a new set of spark plugs and add premium octane fuel for a cleaner engine.
Either the plug wires are bad or the compression on #1 cylinder is low. More input Make sure that you are at the right cylinder, cylinder # 1 on the V-6 is located on the rear head underneath the collector on the passenger side (a pain to get to). Ensure that the coil is producing good spark. There is a tool for this that will light upevery time that spark is produced. If you are getting good spark to the plug and the plug is good, the cylinder's injector may be bad. This can be checked by using an automotive stethoscope, if you are not hearing anything on that particular injector, get a fuel injector test (noid) light. It will plug into the wire harness of that injector it will test to ensure that you are getting power to your injector. To test the injector itself, take a ohmmeter to it and check for proper resistance on a 2000 only model resistance should be between 14 & 15 ohms. If all of the tests pass get a compression gauge and check compression on cylinder one.
this could be caused by a fuel problem, not spark. check to see if your getting spark to the plug. ck to see if the injector is firing, and run a compression test on that cylinder
If it is just one injector, it is a bad injector or a problem in the wiring harness or connector for that injector. If it is all of the injectors, it could be a fuse, the entire injector harness, a broken loose or unplugged connector on the injector harness, or the fuel pump or fuel pressure regulator.