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There's lots of possible answers to this. If you want an easy one, the Civil War led to the Thirteenth, Fourteenth, and Fifteenth amendments.
abolition
Jonathan Edwards' sermons persuaded colonists to petition the royal governor, which led to the abolition of tariffs.
American Association for the Abolition of Involuntary Mental Hospitalization was created in 1970.
Frederick Douglass, William Lloyd Garrison and other former slaves was involve in the abolition movement.