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Cane toads have become an ecological disaster in Australia. They eat the native wildlife, but have no natural predators. Cand toads eat native frog species, as well as other small burds and mammals, and they compete directly with native frogs and other species for food. Many native frog species are at risk of extinction as a result of the cane toad population.

The only animals that have worked out how to eat them safely are crows, which flip the toads over and eat the soft underbelly, where there are no poison glands. Northern quolls have suffered huge population losses because habitat loss and the resultant drop in food sources has driven them to try to eat the cane toad, which has, of course, poisoned these mammals. Any native animal that normally eats frogs will be poisoned by the cane toad.

Cane toads are also continuing to spread south. They are remarkably adaptable creatures, and seem to be becoming hardier, adapting to a wide variety of habitats and climate conditions. They also breed prolifically, and wherever they populate, they push out the native species.

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