Nero was alleged to have killed his step brother by poison.
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Tiberius' brother was Drusus (Nero Claudius Drusus Germanicus)
Nero ordered the execution of Saint Peter. He used the excuse that Christians were responsible for the fire that burned a large part of the city of Rome. He needed to hide his own blame for causing the fire.
Ptolemy XIII was the brother who was at war with Cleopatra and would have liked her dead.
Tiberius, Augustus' step-son Caligula, the son of Germanicus Caesar who should have succeded Tiberius but was killed by him Cladius, the brother to Germanicus and uncle to Caligula Nero, the grandson of Germanicus Caesar, the son of one of his daughters. This ends the Julio-Claudian Line.
Cleopatra killed her brother in 44 BC when they returned to Egypt from Rome after Caesar's murder.