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First attest in English 1382, "affliction, calamity, evil, scourge," also "malignant disease," from Middle French plague, from Later Latin plaga, used in Vulgate Latin Bible for "pestilence," from Latin plaga "stroke, wound," probably from root of plangere "to strike, lament (by beating the breast)," from or cognate with Greek (Doric) plaga "blow," from ProtoIndoEuropean *plag- "hit" (cf. Old English flocan "to strike, beat," Gothic flokan "to bewail," Germanic fluchen, OldFriesian floka "to curse"). Old Irish Gaelic plag (genitive plaige) "plague, pestilence" is from Latin, specifically as referent to "Bubonic Plague" from 1601. The verb is from 1481; in the sense of "bother, annoy" it is first recorded 1594. Plaguey "vexatious" is attested from 1615.

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