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The Permian-Triassic extinction, the most severe mass extinction event in Earth's history, significantly impacted marine life, particularly the trilobites and the coral reefs. Trilobites, which had thrived for hundreds of millions of years, became extinct, while many coral species and other marine organisms also faced catastrophic declines. Terrestrial life was not spared, with many amphibians and early reptiles suffering extensive losses. Overall, the event marked a dramatic shift in biodiversity, paving the way for the dominance of new groups in the Mesozoic era.

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