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No , they damage the suface , you can use an water based paint , but it will only lay a film ontop and won't "key " into the surface, if you call the technical department of a paint manufacturer for further info

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Q: Can oil paints be used on perspex without damaging the surface. Hydrocarbons often dissolve materials like perspex and some plastics from which containers are made. I want to paint perspex?
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