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No, Aspartame has not been associated with side effects. However, having intensely sweet things such as Diet Soda makes people less willing to enjoy the not-so-intense sweetness of something like a tomato, apple, or pear. This leads people to choose nutritionally poor diets. In addition, it has been theorized that because our bodies often use sweetness to determine how many calories we've consumed [left over from our hunter-gatherer days], we can get desensitized to sweet things and want to consume more to get what our bodies consider the right ammount of calories. This can lead to overeating.

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