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Chicago, IL - Results of a phase 3, randomized, double-blind study show that febuxostat (TAP Pharmaceutical Products) is more effective in lowering serum uric acid than the current standard of care, allopurinol. "We have a potential alternative for patients with gout," lead investigator Dr Michael Becker (University of Chicago Pritzker School of Medicine, Chicago, IL) told renal wire . "This is an area that has been static for 40 years, and febuxostat may represent a new option for treating these patients, particularly those with renal insufficiency." The company-sponsored findings appear in the December 8, 2005 issue of the New England Journal of Medicine [ 1 ].

While proponents and critics both agree that a treatment alternative for gout is long overdue and febuxostat is showing promise, some argue that the limitations of the present trial overestimate its benefit over allopurinol.

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