0
Circulating immune complexes (CIC) are present in many individuals with systemic lupus erythematosus (SLE) and Rheumatoid Arthritis (RA), especially with any of the vasculitides complications. Levels of CICs have been reported to show correlation with disease activity in that higher levels are reported during active phases of the disease. Many tests have been developed for the detection of CICs, including PEG precipitation, radial immunodiffusion and cellular based assays, such as the Raji cell assay. No single procedure appears to detect all types of CIC: however, those procedures which detect CICs containing fragments of complement (e.g. C1q and C3d) appear to detect clinically relevant events. C1q binds with greatest avidity to immune complexes ranging in size from 19 to 27 S. In serum sickness, which is the prototype immune complex disease, this size of complex has typically been found to be deposited in tissues leading to damage. The IBL test system for C1q circulating immune complexes detects immune complexes containing both C1q and IgG. The concentration is expressed as µg/ml heat aggregated human globulin (HAG) equivalents. IBL also offers a test kit for the determination of C3d and IgG containing circulating immune complexes.
(source RDI Division of Fitzgerald Industries Intl 34 Junction Square Drive Concord MA 01742-3049 )
Wiki User
∙ 11y ago
Wiki User
∙ 13y agoThese tests evaluate the immune system, whose function is to defend the body against such invaders as bacteria and viruses.
Add your answer:
Earn +20 pts
Do you think that taking supplements to boost my immune system will make my immune system more reactive instead of calming it down if I have arthritis and my immune system is already hyperactive?
If you have an an inflammatory form of arthritis like for example RA it is the immune system that is attacking your joints and you need to treat it by suppressing the immune system to a degree. you would be wise to check with your doctor what treatments are best for you to self administer in any case.
Pictures of complex machines?
The automobile. Never in history has a machine this complex been given and operated by the general public to operate and repair.
What about the complex formation ability of lanthanides as campared to actinides?
describe the complex formation by lanthanides?
Is a jellyfish more complex then an earthworm?
No a worm is more complex than a jellyfish
What is imflamitory arthritis?
Rheumatoid arthritis. This disease is the result of the immune system mistakenly turning on its own body and destroying connective tissu such as cartilage. It can also affect many other parts of the body.
What is the purpose of an immune complex test?
The purpose of the immune complex test is to demonstrate circulating immune complexes in the blood, to estimate the severity of immune complex disease, and to monitor response to therapy.
What characteristics does a normal immune complex test have?
Normally, immune complexes are not detected in the blood.
How should patients be prepared for an immune complex test?
This test requires a blood sample. It is not necessary for the patient to be in a fasting (nothing to eat or drink) state before the test.
Assessment of immune complex in tissues?
The value of three immune complex assays in the management of systemic lupus erythematosus: an assessment of immune complex levels, size and immunochemical properties in relation to disease activity and manifestations.
What precautions need to be taken when doing an immune complex test?
Because this test is requested when the physician suspects that a patient's immune system is not functioning properly, special care should be taken during and after blood is drawn. For example, the venipuncture site should be kept clean.
How is an immune complex test done?
The method generally used for detecting immune complexes is examination of a tissue obtained by biopsy (removal and examination of tissue sample) and the subsequent use of different staining techniques with specific antibodies.
What characteristics does an abnormal immune complex test have?
The presence of detectable immune complexes in the blood is important in the diagnosis of autoimmune diseases, such as SLE and rheumatoid arthritis. However, for definitive diagnosis, the results of other studies must be considered.
What risks exist for the patient in undergoing an immune complex test?
Risks for this test are minimal, but may include slight bleeding from the blood-drawing site, fainting or feeling lightheaded after venipuncture, or hematoma (blood accumulating under the puncture site).
How do asbestos test effect your immune system?
Exposure to asbestos will likely compromise the immune system because of the long-term stress to the body. The test for asbestos exposure does not affect the immune system.
When was Rocket Propulsion Test Complex created?
Rocket Propulsion Test Complex was created in 1965.
How do antigen-antibody complex protect the body?
by producing an immune response
Major histocompatibility complex mch is important in?
The immune system and transplant medicine.
