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Serious defects from teratogens are most likely to occur during the critical periods of organogenesis, which typically occurs between the 3rd and 8th week of pregnancy. During this time, the developing fetus is particularly vulnerable as major organs and structures are forming. Exposure to teratogens during this window can lead to significant congenital anomalies. After this period, the risk of serious defects generally decreases, although exposure can still have adverse effects.

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