People with systemic lupus erythematosus have double the risk of cardiovascular events. There are several reasons. Lupus is inflammatory. The inflammation affects the blood vessels ultimately reducing elasticity and increasing the likelihood of atherosclerosis (hardening of the arteries). Prednisone, used to treat lupus, also increases the change of atherosclerosis. Some lupus patients experience inflammation of the heart (pericarditis, endocarditis, myocarditis). The pain and fatigue that accompany lupus make those with the disease less likely to exercise thereby increasing the risk of heart attack and stroke. The sedentary lifestyle and some of the medcations predispose the lupus patient to obesity, another risk factor in cardiovascular events. The stress and depression that accompany living with an unpredictable chronic condition increase the risk even more. Lupus patients may also have some of the clotting factors (anticardiolipin, lupus anticoagulant, antiphospholipid antibodies) that cause blood clots. Lupus may result anemia, or irregular sizes in red blood cells affecting the amount of oxygen that gets to the heart muscle.
The left ventricle pumps blood to the systemic loop.
no
systemic circulation .
yes.
coronary circulation
Systemic Lupus Erythematosus (SLE)
Targets may include the brain, kidneys, heart, pancreas, or other organs
There are 3 main types of lupus (that i know of): '''Drug-Induced lupus''' (lasting only for the duration of the medication causing it) '''Discoid lupus''' (effecting mainly the skin and extremities) '''Systemic lupus erythematosus''' (effecting almost everything; kidneys, brain, heart, lungs, skin, joints, muscles)
most systemic lupus patients eventually die from infections or from heart disease complicated by long-term use of corticosteroids
Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that is potentially debilitating and sometimes fatal as the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remission. Lupus can occur at any age, and is most common in women, particularly of non-European descent. Lupus is treatable symptomatically, mainly with corticosteroids and immunosuppressants, though there is currently no cure.== == The word itself is also Latin for Wolf
Systemic lupus erythematosus affects each patient differently. Lupus is always marked by inflammation which is the result of autoimmune activity. The majority of people with lupus have joint and muscle pain along with profound fatigue. Half of them have lupus kidney disease. The chronic inflammation greatly increases the risk of cardiovascular disease. The three leading causes of death in lupus are uncontrolled infection, kidney failure and heart attacks/strokes. Lupus can affect any other organ in the body.
Toni Braxton was diagnosed in 2008 when she was hospitalized with what doctors thought was a heart attack. On further in vestigation, the doctors diagnosed her with lupus. Lupus can affect any of the muscle layers of the heart. Lupus patients are 50 times more likely to suffer a heart attack than the general population.
Systemic lupus accounts for approximately 70 percent of all cases of lupus. In approximately half of these cases, a major organ, such as the heart, lungs, kidneys or brain, will be affected. Cutaneous lupus (affecting only the skin) accounts for approximately 10 percent of all lupus cases. Drug-induced lupus accounts for about 10 percent of all lupus cases and is caused by high doses of certain medications. The symptoms of drug-induced lupus are similar to systemic lupus; however, symptoms usually subside when the medications are discontinued.
Functional limitations of a person with systemic lupus erythematosus (SLE) can vary widely depending on the severity of their symptoms. Common limitations may include fatigue, joint pain, muscle weakness, and impaired mobility. SLE can also affect organs such as the kidneys, heart, and lungs, leading to additional functional limitations.
Lupus can affect virtually every body system. For some people, there is no organ involvement. 50% of people with lupus will have kidney disease. Lupus frequently affects the heart and lungs. Pericarditis and pleurisy are common. Lupus can affect the central nervous system causing seizures, headaches, and cognitive impairment. Involvement of other body systems is less common but does occur. Lupus frequently occurs in overlap with other autoimmune conditions. In those cases, it is difficult to determine which disease is causing which damage.
Lupus can affect the brain, heart, skin, kidneys, liver, lymph nodes, stomach and really any organ in the human body. Approximately 40% of people wth systemic lupus erythematosus will develop lupus nephritis (kidney disease).
A) Rheumatoid arthritis; start methotrexate. B) Systemic lupus erythematosus (SLE); start hydroxychloroquine. C) Psoriatic arthritis; start topical corticosteroids. D) Osteoarthritis; start acetaminophen. E) Gout; start colchicine.