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A thrombus in the left anterior descending artery (LAD) interrupts blood flow to the majority of the heart, particularly the left side of the heart. When blood flow to this part of the heart is interrupted, the heart has trouble doing its job of delivering blood to the body. Critical structures including the brain do not receive the blood they require, and consequently, they and the individual die.

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Arteries supply oxygenated blood, a clot in any main arteries will cut off oxygen supplies.

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